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- W2027983183 abstract "Human cytidine deaminases, including APOBEC3G (A3G) and A3F, are part of a cellular defense system against retroviruses and retroelements including non-LTR retrotransposons LINE-1 (L1) and Alu. Expression of cellular A3 proteins is sufficient for inhibition of L1 and Alu retrotransposition, but the effect of A3 proteins transferred in exosomes on retroelement mobilization is unknown. Here, we demonstrate for the first time that exosomes secreted by CD4(+)H9 T cells and mature monocyte-derived dendritic cells encapsidate A3G and A3F and inhibit L1 and Alu retrotransposition. A3G is the major contributor to the inhibitory activity of exosomes, however, the contribution of A3F in H9 exosomes cannot be excluded. Additionally, we show that exosomes encapsidate mRNAs coding for A3 proteins. A3G mRNA, and less so A3F, was enriched in exosomes secreted by H9 cells. Exosomal A3G mRNA was functional in vitro. Whether exosomes inhibit retrotransposons in vivo requires further investigation." @default.
- W2027983183 created "2016-06-24" @default.
- W2027983183 creator A5010739983 @default.
- W2027983183 creator A5031009872 @default.
- W2027983183 creator A5051851456 @default.
- W2027983183 creator A5075950481 @default.
- W2027983183 date "2010-04-01" @default.
- W2027983183 modified "2023-10-16" @default.
- W2027983183 title "Inhibition of LINE-1 and Alu retrotransposition by exosomes encapsidating APOBEC3G and APOBEC3F" @default.
- W2027983183 cites W1555041989 @default.
- W2027983183 cites W1762620449 @default.
- W2027983183 cites W1959325762 @default.
- W2027983183 cites W1966477735 @default.
- W2027983183 cites W1967367827 @default.
- W2027983183 cites W1974134624 @default.
- W2027983183 cites W1978325079 @default.
- W2027983183 cites W1978596306 @default.
- W2027983183 cites W1980834036 @default.
- W2027983183 cites W1981932058 @default.
- W2027983183 cites W1986319478 @default.
- W2027983183 cites W1994599395 @default.
- W2027983183 cites W1998154426 @default.
- W2027983183 cites W1999676455 @default.
- W2027983183 cites W2001375348 @default.
- W2027983183 cites W2006699168 @default.
- W2027983183 cites W2007589425 @default.
- W2027983183 cites W2007856011 @default.
- W2027983183 cites W2015820342 @default.
- W2027983183 cites W2016732725 @default.
- W2027983183 cites W2017916825 @default.
- W2027983183 cites W2021861291 @default.
- W2027983183 cites W2022502045 @default.
- W2027983183 cites W2023540573 @default.
- W2027983183 cites W2023865653 @default.
- W2027983183 cites W2029884547 @default.
- W2027983183 cites W2030701238 @default.
- W2027983183 cites W2032235371 @default.
- W2027983183 cites W2033464993 @default.
- W2027983183 cites W2033631070 @default.
- W2027983183 cites W2035395679 @default.
- W2027983183 cites W2036374978 @default.
- W2027983183 cites W2042797749 @default.
- W2027983183 cites W2042851494 @default.
- W2027983183 cites W2048560318 @default.
- W2027983183 cites W2049365377 @default.
- W2027983183 cites W2050557699 @default.
- W2027983183 cites W2052509237 @default.
- W2027983183 cites W2054143743 @default.
- W2027983183 cites W2054637102 @default.
- W2027983183 cites W2055313665 @default.
- W2027983183 cites W2058289123 @default.
- W2027983183 cites W2059399597 @default.
- W2027983183 cites W2059902195 @default.
- W2027983183 cites W2070677647 @default.
- W2027983183 cites W2071660897 @default.
- W2027983183 cites W2073406070 @default.
- W2027983183 cites W2074247685 @default.
- W2027983183 cites W2075881651 @default.
- W2027983183 cites W2076559238 @default.
- W2027983183 cites W2086275775 @default.
- W2027983183 cites W2086739233 @default.
- W2027983183 cites W2087678694 @default.
- W2027983183 cites W2088667759 @default.
- W2027983183 cites W2091279754 @default.
- W2027983183 cites W2096197897 @default.
- W2027983183 cites W2096292882 @default.
- W2027983183 cites W2101039666 @default.
- W2027983183 cites W2111079470 @default.
- W2027983183 cites W2118323715 @default.
- W2027983183 cites W2120034162 @default.
- W2027983183 cites W2123875414 @default.
- W2027983183 cites W2124373678 @default.
- W2027983183 cites W2130676809 @default.
- W2027983183 cites W2133299937 @default.
- W2027983183 cites W2134114724 @default.
- W2027983183 cites W2136460560 @default.
- W2027983183 cites W2138016410 @default.
- W2027983183 cites W2141407506 @default.
- W2027983183 cites W2144623802 @default.
- W2027983183 cites W2150649207 @default.
- W2027983183 cites W2152480547 @default.
- W2027983183 cites W2153495666 @default.
- W2027983183 cites W2153586836 @default.
- W2027983183 cites W2154215235 @default.
- W2027983183 cites W2156063578 @default.
- W2027983183 cites W2156836754 @default.
- W2027983183 cites W2157876432 @default.
- W2027983183 cites W2162146849 @default.
- W2027983183 cites W2166488270 @default.
- W2027983183 cites W2167782755 @default.
- W2027983183 cites W2169315049 @default.
- W2027983183 cites W2170379872 @default.
- W2027983183 cites W2171338663 @default.
- W2027983183 doi "https://doi.org/10.1016/j.virol.2010.01.021" @default.
- W2027983183 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2851184" @default.
- W2027983183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20153011" @default.
- W2027983183 hasPublicationYear "2010" @default.
- W2027983183 type Work @default.