Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027987777> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2027987777 endingPage "163" @default.
- W2027987777 startingPage "163" @default.
- W2027987777 abstract "Changes in the microbiota composition have been implicated in the development of obesity and type 2 diabetes. However, not much is known on the involvement of gut microbiota in lipid and cholesterol metabolism. In addition, the gut microbiota might also be a potential source of plasma oxyphytosterol and oxycholesterol concentrations (oxidation products of plant sterols and cholesterol). Therefore, the aim of this study was to modulate the gut microbiota by antibiotic therapy to investigate effects on parameters reflecting cholesterol metabolism and oxyphytosterol concentrations.A randomized, double blind, placebo-controlled trial was performed in which 55 obese, pre-diabetic men received oral amoxicillin (broad-spectrum antibiotic), vancomycin (antibiotic directed against Gram-positive bacteria) or placebo (microcrystalline cellulose) capsules for 7 days (1500 mg/day). Plasma lipid and lipoprotein, non-cholesterol sterol, bile acid and oxy(phyto)sterol concentrations were determined at baseline and after 1-week intervention.Plasma secondary bile acids correlated negatively with cholestanol (marker for cholesterol absorption, r = −0.367; P < 0.05) and positively with lathosterol concentrations (marker for cholesterol synthesis, r = 0.430; P < 0.05). Fasting plasma secondary bile acid concentrations were reduced after vancomycin treatment as compared to placebo treatment (-0.24 ± 0.22 μmol/L vs. −0.08 ± 0.29 μmol/L; P < 0.01). Vancomycin and amoxicillin treatment did not affect markers for cholesterol metabolism, plasma TAG, total cholesterol, LDL-C or HDL-C concentrations as compared to placebo. In addition, both antibiotic treatments did not affect individual isoforms or total plasma oxyphytosterol or oxycholesterol concentrations.Despite strong correlations between plasma bile acid concentrations and cholesterol metabolism (synthesis and absorption), amoxicillin and vancomycin treatment for 7 days did not affect plasma lipid and lipoprotein, plasma non-cholesterol sterol and oxy(phyto)sterol concentrations in obese, pre-diabetic men." @default.
- W2027987777 created "2016-06-24" @default.
- W2027987777 creator A5008496074 @default.
- W2027987777 creator A5013743812 @default.
- W2027987777 creator A5026037676 @default.
- W2027987777 creator A5027728671 @default.
- W2027987777 creator A5029839840 @default.
- W2027987777 creator A5044579935 @default.
- W2027987777 creator A5082833203 @default.
- W2027987777 date "2005-04-01" @default.
- W2027987777 modified "2023-10-18" @default.
- W2027987777 title "T04-P-044 The impact of plasma homocysteine level on neointimal proliferation in patients after PCI with reduced barotrauma" @default.
- W2027987777 doi "https://doi.org/10.1016/s1567-5688(05)80635-x" @default.
- W2027987777 hasPublicationYear "2005" @default.
- W2027987777 type Work @default.
- W2027987777 sameAs 2027987777 @default.
- W2027987777 citedByCount "0" @default.
- W2027987777 crossrefType "journal-article" @default.
- W2027987777 hasAuthorship W2027987777A5008496074 @default.
- W2027987777 hasAuthorship W2027987777A5013743812 @default.
- W2027987777 hasAuthorship W2027987777A5026037676 @default.
- W2027987777 hasAuthorship W2027987777A5027728671 @default.
- W2027987777 hasAuthorship W2027987777A5029839840 @default.
- W2027987777 hasAuthorship W2027987777A5044579935 @default.
- W2027987777 hasAuthorship W2027987777A5082833203 @default.
- W2027987777 hasConcept C126322002 @default.
- W2027987777 hasConcept C134018914 @default.
- W2027987777 hasConcept C185592680 @default.
- W2027987777 hasConcept C2778163477 @default.
- W2027987777 hasConcept C2778718757 @default.
- W2027987777 hasConcept C2779399885 @default.
- W2027987777 hasConcept C2780022283 @default.
- W2027987777 hasConcept C2781471481 @default.
- W2027987777 hasConcept C501593827 @default.
- W2027987777 hasConcept C539455810 @default.
- W2027987777 hasConcept C55493867 @default.
- W2027987777 hasConcept C62746215 @default.
- W2027987777 hasConcept C71924100 @default.
- W2027987777 hasConceptScore W2027987777C126322002 @default.
- W2027987777 hasConceptScore W2027987777C134018914 @default.
- W2027987777 hasConceptScore W2027987777C185592680 @default.
- W2027987777 hasConceptScore W2027987777C2778163477 @default.
- W2027987777 hasConceptScore W2027987777C2778718757 @default.
- W2027987777 hasConceptScore W2027987777C2779399885 @default.
- W2027987777 hasConceptScore W2027987777C2780022283 @default.
- W2027987777 hasConceptScore W2027987777C2781471481 @default.
- W2027987777 hasConceptScore W2027987777C501593827 @default.
- W2027987777 hasConceptScore W2027987777C539455810 @default.
- W2027987777 hasConceptScore W2027987777C55493867 @default.
- W2027987777 hasConceptScore W2027987777C62746215 @default.
- W2027987777 hasConceptScore W2027987777C71924100 @default.
- W2027987777 hasIssue "1" @default.
- W2027987777 hasLocation W20279877771 @default.
- W2027987777 hasOpenAccess W2027987777 @default.
- W2027987777 hasPrimaryLocation W20279877771 @default.
- W2027987777 hasRelatedWork W1984155300 @default.
- W2027987777 hasRelatedWork W2011163402 @default.
- W2027987777 hasRelatedWork W2021921406 @default.
- W2027987777 hasRelatedWork W2028348279 @default.
- W2027987777 hasRelatedWork W2032958076 @default.
- W2027987777 hasRelatedWork W2048064917 @default.
- W2027987777 hasRelatedWork W2059865744 @default.
- W2027987777 hasRelatedWork W2091911513 @default.
- W2027987777 hasRelatedWork W4225694854 @default.
- W2027987777 hasRelatedWork W4235478739 @default.
- W2027987777 hasVolume "6" @default.
- W2027987777 isParatext "false" @default.
- W2027987777 isRetracted "false" @default.
- W2027987777 magId "2027987777" @default.
- W2027987777 workType "article" @default.