FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027992078> ?p ?o ?g. }

• W2027992078 endingPage "2979" @default.
• W2027992078 startingPage "2971" @default.
• W2027992078 abstract "A new series of acid- and urea-functionalized polycarbonate block copolymers were synthesized via organocatalytic living ring-opening polymerization using methoxy poly(ethylene glycol) (PEG) as a macroinitiator to form micelles as drug delivery carriers. The micelles were characterized for critical micelle concentration, particle size and size distribution, kinetic stability and loading capacity for a model anticancer drug, doxorubicin (DOX) having an amine group. The acid/urea groups were placed in block forms (i.e. acid as the middle block or the end block) or randomly distributed in the polycarbonate block to investigate molecular structure effect. The micelles formed from the polymers in both random and block forms provided high drug loading capacity due to strong ionic interaction between the acid in the polymer and the amine in DOX. However, the polymers with acid and urea groups placed in the block forms formed micelles with wider size distribution (two size populations), and their DOX-loaded micelles were less stable. The number of acid/urea groups in the random form was further varied from 5 to 8, 13 and 19 to study its effects on self-assembly behaviors and DOX loading. An increased number of acid/urea groups yielded DOX-loaded micelles with smaller size and enhanced kinetic stability because of improved inter-molecular polycarbonate-polycarbonate (urea-urea and urea-acid) hydrogen-bonding and polycarbonate-DOX (acid-amine) ionic interactions. However, when the number of acid/urea groups was 13 or higher, micelles aggregated in a serum-containing medium, and freeze-dried DOX-loaded micelles were unable to re-disperse in an aqueous solution. Among all the polymers synthesized in this study, 1b with 8 acid/urea groups in the random form had the optimum properties. In vitro release studies showed that DOX release from 1b micelles was sustained over 7 h without significant initial burst release. MTT assays demonstrated that the polymer was not toxic towards HepG2 and HEK293 cells. Importantly, DOX-loaded micelles were potent against HepG2 cells with IC(50) of 0.26 mg/L, comparable to that of free DOX (IC(50): 0.20 mg/L). In addition, DOX-loaded 1b micelles yielded lower DOX content in the heart tissue of the tested mice as compared to free DOX formulation after i.v. injection. These findings signify that 1b micelles may be a promising carrier for delivery of anticancer drugs that contain amine groups." @default.
• W2027992078 created "2016-06-24" @default.
• W2027992078 creator A5008757733 @default.
• W2027992078 creator A5040144386 @default.
• W2027992078 creator A5046543918 @default.
• W2027992078 creator A5048183118 @default.
• W2027992078 creator A5050726920 @default.
• W2027992078 creator A5067480713 @default.
• W2027992078 creator A5087768520 @default.
• W2027992078 date "2012-04-01" @default.
• W2027992078 modified "2023-10-14" @default.
• W2027992078 title "The role of non-covalent interactions in anticancer drug loading and kinetic stability of polymeric micelles" @default.
• W2027992078 cites W1973230016 @default.
• W2027992078 cites W1976371089 @default.
• W2027992078 cites W1982589292 @default.
• W2027992078 cites W1983213137 @default.
• W2027992078 cites W1984761779 @default.
• W2027992078 cites W1986857845 @default.
• W2027992078 cites W1991576334 @default.
• W2027992078 cites W2001413029 @default.
• W2027992078 cites W2012996914 @default.
• W2027992078 cites W2013311947 @default.
• W2027992078 cites W2029677759 @default.
• W2027992078 cites W2045499557 @default.
• W2027992078 cites W2049930363 @default.
• W2027992078 cites W2054609339 @default.
• W2027992078 cites W2054688174 @default.
• W2027992078 cites W2054745605 @default.
• W2027992078 cites W2056347214 @default.
• W2027992078 cites W2057000213 @default.
• W2027992078 cites W2066888617 @default.
• W2027992078 cites W2069360982 @default.
• W2027992078 cites W2071636590 @default.
• W2027992078 cites W2077506251 @default.
• W2027992078 cites W2080673412 @default.
• W2027992078 cites W2082545019 @default.
• W2027992078 cites W2082587127 @default.
• W2027992078 cites W2088862035 @default.
• W2027992078 cites W2090555680 @default.
• W2027992078 cites W2091796668 @default.
• W2027992078 cites W2092060110 @default.
• W2027992078 cites W2099352996 @default.
• W2027992078 cites W2115885503 @default.
• W2027992078 cites W2153088789 @default.
• W2027992078 doi "https://doi.org/10.1016/j.biomaterials.2011.11.035" @default.
• W2027992078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22244697" @default.
• W2027992078 hasPublicationYear "2012" @default.
• W2027992078 type Work @default.
• W2027992078 sameAs 2027992078 @default.
• W2027992078 citedByCount "128" @default.
• W2027992078 countsByYear W20279920782012 @default.
• W2027992078 countsByYear W20279920782013 @default.
• W2027992078 countsByYear W20279920782014 @default.
• W2027992078 countsByYear W20279920782015 @default.
• W2027992078 countsByYear W20279920782016 @default.
• W2027992078 countsByYear W20279920782017 @default.
• W2027992078 countsByYear W20279920782018 @default.
• W2027992078 countsByYear W20279920782019 @default.
• W2027992078 countsByYear W20279920782020 @default.
• W2027992078 countsByYear W20279920782021 @default.
• W2027992078 countsByYear W20279920782022 @default.
• W2027992078 countsByYear W20279920782023 @default.
• W2027992078 crossrefType "journal-article" @default.
• W2027992078 hasAuthorship W2027992078A5008757733 @default.
• W2027992078 hasAuthorship W2027992078A5040144386 @default.
• W2027992078 hasAuthorship W2027992078A5046543918 @default.
• W2027992078 hasAuthorship W2027992078A5048183118 @default.
• W2027992078 hasAuthorship W2027992078A5050726920 @default.
• W2027992078 hasAuthorship W2027992078A5067480713 @default.
• W2027992078 hasAuthorship W2027992078A5087768520 @default.
• W2027992078 hasConcept C10138342 @default.
• W2027992078 hasConcept C11268172 @default.
• W2027992078 hasConcept C127413603 @default.
• W2027992078 hasConcept C131779359 @default.
• W2027992078 hasConcept C15920480 @default.
• W2027992078 hasConcept C162324750 @default.
• W2027992078 hasConcept C178790620 @default.
• W2027992078 hasConcept C184651966 @default.
• W2027992078 hasConcept C185592680 @default.
• W2027992078 hasConcept C188027245 @default.
• W2027992078 hasConcept C192562407 @default.
• W2027992078 hasConcept C2776540798 @default.
• W2027992078 hasConcept C2777516009 @default.
• W2027992078 hasConcept C2780365088 @default.
• W2027992078 hasConcept C42360764 @default.
• W2027992078 hasConcept C521977710 @default.
• W2027992078 hasConcept C54400483 @default.
• W2027992078 hasConceptScore W2027992078C10138342 @default.
• W2027992078 hasConceptScore W2027992078C11268172 @default.
• W2027992078 hasConceptScore W2027992078C127413603 @default.
• W2027992078 hasConceptScore W2027992078C131779359 @default.
• W2027992078 hasConceptScore W2027992078C15920480 @default.
• W2027992078 hasConceptScore W2027992078C162324750 @default.
• W2027992078 hasConceptScore W2027992078C178790620 @default.
• W2027992078 hasConceptScore W2027992078C184651966 @default.
• W2027992078 hasConceptScore W2027992078C185592680 @default.
• W2027992078 hasConceptScore W2027992078C188027245 @default.
• W2027992078 hasConceptScore W2027992078C192562407 @default.

• next