FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028001817> ?p ?o ?g. }

• W2028001817 endingPage "794" @default.
• W2028001817 startingPage "785" @default.
• W2028001817 abstract "S100P is a small calcium-binding protein of the S100 EF-hand-containing family of proteins. Elevated levels of its mRNA are reported to be associated with the progression to hormone independence and metastasis of prostate cancer and to be associated with loss of senescence in human breast epithelial cells in vitro. The first structure of human recombinant S100P in calcium-bound form is now reported at 2.0A resolution by X-ray diffraction. A flexible linker connects the two EF-hand motifs. The protein exists as a homodimer formed by non-covalent interactions between large hydrophobic areas on monomeric S100P. Experiments with an optical biosensor to study binding parameters of the S100P monomer interaction showed that the association rate constant was faster in the presence of calcium than in their absence, whereas the dissociation rate constant was independent of calcium. The K(d) values were 64(+/-24)nM and 2.5(+/-0.8) microM in the presence and in the absence of calcium ions, respectively. Dimerization of S100P is demonstrated in vivo using the yeast two-hybrid system. The effect of mutation of specific amino acids suggests that dimerization in vivo can be affected by amino acids on the dimer interface and in the hydrophobic core." @default.
• W2028001817 created "2016-06-24" @default.
• W2028001817 creator A5002287326 @default.
• W2028001817 creator A5015077830 @default.
• W2028001817 creator A5026067667 @default.
• W2028001817 creator A5027377891 @default.
• W2028001817 creator A5032173201 @default.
• W2028001817 creator A5052559364 @default.
• W2028001817 creator A5056028884 @default.
• W2028001817 creator A5089425163 @default.
• W2028001817 date "2003-01-01" @default.
• W2028001817 modified "2023-10-03" @default.
• W2028001817 title "The Crystal Structure at 2Å Resolution of the Ca2+-binding Protein S100P" @default.
• W2028001817 cites W1524492065 @default.
• W2028001817 cites W1537094542 @default.
• W2028001817 cites W1566315211 @default.
• W2028001817 cites W1599096372 @default.
• W2028001817 cites W1682158591 @default.
• W2028001817 cites W1968507864 @default.
• W2028001817 cites W1980759649 @default.
• W2028001817 cites W1986191025 @default.
• W2028001817 cites W1990322093 @default.
• W2028001817 cites W1990955455 @default.
• W2028001817 cites W1995017064 @default.
• W2028001817 cites W1998813486 @default.
• W2028001817 cites W2001641653 @default.
• W2028001817 cites W2013083986 @default.
• W2028001817 cites W2015223415 @default.
• W2028001817 cites W2028231353 @default.
• W2028001817 cites W2031183930 @default.
• W2028001817 cites W2034373769 @default.
• W2028001817 cites W2037198241 @default.
• W2028001817 cites W2045252643 @default.
• W2028001817 cites W2049110191 @default.
• W2028001817 cites W2050341653 @default.
• W2028001817 cites W2054159684 @default.
• W2028001817 cites W2060913542 @default.
• W2028001817 cites W2079290629 @default.
• W2028001817 cites W2080981546 @default.
• W2028001817 cites W2082625715 @default.
• W2028001817 cites W2089697399 @default.
• W2028001817 cites W2097493124 @default.
• W2028001817 cites W2106315897 @default.
• W2028001817 cites W2124706727 @default.
• W2028001817 cites W2129771435 @default.
• W2028001817 cites W2143067079 @default.
• W2028001817 cites W2145647064 @default.
• W2028001817 cites W2150180767 @default.
• W2028001817 cites W2397781043 @default.
• W2028001817 cites W4248451563 @default.
• W2028001817 doi "https://doi.org/10.1016/s0022-2836(02)01278-0" @default.
• W2028001817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12507480" @default.
• W2028001817 hasPublicationYear "2003" @default.
• W2028001817 type Work @default.
• W2028001817 sameAs 2028001817 @default.
• W2028001817 citedByCount "56" @default.
• W2028001817 countsByYear W20280018172012 @default.
• W2028001817 countsByYear W20280018172013 @default.
• W2028001817 countsByYear W20280018172014 @default.
• W2028001817 countsByYear W20280018172015 @default.
• W2028001817 countsByYear W20280018172016 @default.
• W2028001817 countsByYear W20280018172017 @default.
• W2028001817 countsByYear W20280018172018 @default.
• W2028001817 countsByYear W20280018172019 @default.
• W2028001817 countsByYear W20280018172020 @default.
• W2028001817 countsByYear W20280018172021 @default.
• W2028001817 countsByYear W20280018172022 @default.
• W2028001817 countsByYear W20280018172023 @default.
• W2028001817 crossrefType "journal-article" @default.
• W2028001817 hasAuthorship W2028001817A5002287326 @default.
• W2028001817 hasAuthorship W2028001817A5015077830 @default.
• W2028001817 hasAuthorship W2028001817A5026067667 @default.
• W2028001817 hasAuthorship W2028001817A5027377891 @default.
• W2028001817 hasAuthorship W2028001817A5032173201 @default.
• W2028001817 hasAuthorship W2028001817A5052559364 @default.
• W2028001817 hasAuthorship W2028001817A5056028884 @default.
• W2028001817 hasAuthorship W2028001817A5089425163 @default.
• W2028001817 hasConcept C122229402 @default.
• W2028001817 hasConcept C12554922 @default.
• W2028001817 hasConcept C166940927 @default.
• W2028001817 hasConcept C170493617 @default.
• W2028001817 hasConcept C178790620 @default.
• W2028001817 hasConcept C185592680 @default.
• W2028001817 hasConcept C2779546866 @default.
• W2028001817 hasConcept C51639874 @default.
• W2028001817 hasConcept C519063684 @default.
• W2028001817 hasConcept C521977710 @default.
• W2028001817 hasConcept C55493867 @default.
• W2028001817 hasConcept C74998103 @default.
• W2028001817 hasConcept C8010536 @default.
• W2028001817 hasConcept C86803240 @default.
• W2028001817 hasConceptScore W2028001817C122229402 @default.
• W2028001817 hasConceptScore W2028001817C12554922 @default.
• W2028001817 hasConceptScore W2028001817C166940927 @default.
• W2028001817 hasConceptScore W2028001817C170493617 @default.
• W2028001817 hasConceptScore W2028001817C178790620 @default.
• W2028001817 hasConceptScore W2028001817C185592680 @default.
• W2028001817 hasConceptScore W2028001817C2779546866 @default.

• next