Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028003907> ?p ?o ?g. }
- W2028003907 endingPage "2059" @default.
- W2028003907 startingPage "2047" @default.
- W2028003907 abstract "Cell cycle progression through its regulatory control by changes in intracellular Ca2 + levels at the G1/S transition mediates cellular proliferation and viability. Ca2 +/CaM-dependent kinase 1 (CaMKI) appears critical in regulating the assembly of the cyclin D1/cdk4 complex essential for G1 progression, but how this occurs is unknown. Cyclin D1/cdk4 assembly in the early G1 phase is also regulated via binding to p27. Here, we show that a ubiquitin E3 ligase component, F-box protein Fbxl12, mediates CaMKI degradation via a proteasome-directed pathway leading to disruption of cyclin D1/cdk4 complex assembly and resultant G1 arrest in lung epithelia. We also demonstrate that i) CaMKI phosphorylates p27 at Thr157 and Thr198 in human cells and at Thr170 and Thr197 in mouse cells to modulate its subcellular localization; ii) Fbxl12-induced CaMKI degradation attenuates p27 phosphorylation at these sites in early G1 and iii) activation of CaMKI during G1 transition followed by p27 phosphorylation appears to be upstream to other p27 phosphorylation events, an effect abrogated by Fbxl12 overexpression. Lastly, known inducers of G1 arrest significantly increase Fbxl12 levels in cells. Thus, Fbxl12 may be a previously uncharacterized, functional growth inhibitor regulating cell cycle progression that might be used for mechanism-based therapy." @default.
- W2028003907 created "2016-06-24" @default.
- W2028003907 creator A5002497837 @default.
- W2028003907 creator A5020341786 @default.
- W2028003907 creator A5032454329 @default.
- W2028003907 creator A5041285525 @default.
- W2028003907 creator A5048072743 @default.
- W2028003907 creator A5056257626 @default.
- W2028003907 creator A5087456017 @default.
- W2028003907 creator A5087711709 @default.
- W2028003907 date "2013-10-01" @default.
- W2028003907 modified "2023-10-14" @default.
- W2028003907 title "Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I" @default.
- W2028003907 cites W1500240510 @default.
- W2028003907 cites W1599277155 @default.
- W2028003907 cites W178380220 @default.
- W2028003907 cites W1852163795 @default.
- W2028003907 cites W1965049479 @default.
- W2028003907 cites W1965222236 @default.
- W2028003907 cites W1965804002 @default.
- W2028003907 cites W1965907479 @default.
- W2028003907 cites W1969365637 @default.
- W2028003907 cites W1970729835 @default.
- W2028003907 cites W1975308921 @default.
- W2028003907 cites W1975324295 @default.
- W2028003907 cites W1979181492 @default.
- W2028003907 cites W1981557521 @default.
- W2028003907 cites W1982822910 @default.
- W2028003907 cites W1984734982 @default.
- W2028003907 cites W1996695017 @default.
- W2028003907 cites W1998625763 @default.
- W2028003907 cites W1998834185 @default.
- W2028003907 cites W2001486236 @default.
- W2028003907 cites W2005063775 @default.
- W2028003907 cites W2006559604 @default.
- W2028003907 cites W2011412899 @default.
- W2028003907 cites W2011782506 @default.
- W2028003907 cites W2016968116 @default.
- W2028003907 cites W2017931973 @default.
- W2028003907 cites W2021115672 @default.
- W2028003907 cites W2024035512 @default.
- W2028003907 cites W2025246434 @default.
- W2028003907 cites W2027451946 @default.
- W2028003907 cites W2034498291 @default.
- W2028003907 cites W2039008119 @default.
- W2028003907 cites W2039453896 @default.
- W2028003907 cites W2040069945 @default.
- W2028003907 cites W2041405504 @default.
- W2028003907 cites W2044425186 @default.
- W2028003907 cites W2048315213 @default.
- W2028003907 cites W2050446805 @default.
- W2028003907 cites W2052032939 @default.
- W2028003907 cites W2057347947 @default.
- W2028003907 cites W2066700256 @default.
- W2028003907 cites W2070349030 @default.
- W2028003907 cites W2072240092 @default.
- W2028003907 cites W2074112908 @default.
- W2028003907 cites W2077671923 @default.
- W2028003907 cites W2081113123 @default.
- W2028003907 cites W2084312346 @default.
- W2028003907 cites W2087431019 @default.
- W2028003907 cites W2096890855 @default.
- W2028003907 cites W2098990716 @default.
- W2028003907 cites W2101076673 @default.
- W2028003907 cites W2101179323 @default.
- W2028003907 cites W2103732635 @default.
- W2028003907 cites W2106259279 @default.
- W2028003907 cites W2108853055 @default.
- W2028003907 cites W2110564317 @default.
- W2028003907 cites W2111613650 @default.
- W2028003907 cites W2112595206 @default.
- W2028003907 cites W2114347179 @default.
- W2028003907 cites W2115692032 @default.
- W2028003907 cites W2118040139 @default.
- W2028003907 cites W2119419671 @default.
- W2028003907 cites W2125143689 @default.
- W2028003907 cites W2127739281 @default.
- W2028003907 cites W2129398155 @default.
- W2028003907 cites W2129982938 @default.
- W2028003907 cites W2131847309 @default.
- W2028003907 cites W2142154639 @default.
- W2028003907 cites W2154800296 @default.
- W2028003907 cites W2163931326 @default.
- W2028003907 cites W2170024216 @default.
- W2028003907 cites W2322555451 @default.
- W2028003907 doi "https://doi.org/10.1016/j.cellsig.2013.05.012" @default.
- W2028003907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3905573" @default.
- W2028003907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23707388" @default.
- W2028003907 hasPublicationYear "2013" @default.
- W2028003907 type Work @default.
- W2028003907 sameAs 2028003907 @default.
- W2028003907 citedByCount "19" @default.
- W2028003907 countsByYear W20280039072014 @default.
- W2028003907 countsByYear W20280039072015 @default.
- W2028003907 countsByYear W20280039072016 @default.
- W2028003907 countsByYear W20280039072017 @default.
- W2028003907 countsByYear W20280039072018 @default.
- W2028003907 countsByYear W20280039072019 @default.