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• W2028004813 abstract "The relative immunogenicity of tetanus toxin fragment C (TTFC) has been determined in three different strains of inbred mice when expressed in Lactococcus lactis as a membrane-anchored protein (strain UCP1054), as an intracellular protein (strain UCP1050), or as a secreted protein which is partly retained within the cell wall (strain UCP1052). Protection against toxin challenge (20 x LD50) could be obtained without the induction of anti-lactococcal antibodies. When compared in terms of the dose of expressed tetanus toxin fragment C required to elicit protection against lethal challenge the membrane-anchored form was significantly (10-20 fold) more immunogenic than the alternative forms of the protein." @default.
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• W2028004813 date "1996-06-01" @default.
• W2028004813 modified "2023-10-17" @default.
• W2028004813 title "Factors affecting the immunogenicity of tetanus toxin fragment C expressed in<i>Lactococcus lactis</i>" @default.
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• W2028004813 doi "https://doi.org/10.1111/j.1574-695x.1996.tb00284.x" @default.
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