FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028005190> ?p ?o ?g. }

• W2028005190 endingPage "207" @default.
• W2028005190 startingPage "199" @default.
• W2028005190 abstract "Abstract Extracellular glutamate is kept below a toxic level by glial and neuronal glutamate transporters. Here we show that the transportable glutamate uptake inhibitor L‐ trans ‐pyrrolidine‐2,4‐dicarboxylate ( t ‐PDC) induced cell death in mature, but not in immature, hippocampal neuron‐enriched cultures. The cell death produced by a 24‐hr treatment with t ‐PDC was dose‐dependent and reached 85% of the cell population at a 250 μM concentration at 23 days in vitro (DIV). Immunocytochemistry experiments showed that, under these experimental conditions, t ‐PDC killed not only neurons as expected but also glial cells. The N‐methyl‐D‐aspartate (NMDA) antagonist D‐2‐aminophosphonovalerate (D‐APV; 250 μM) only partially reversed this toxicity, completely protecting the neuronal cell population but not the glial population. The antioxidant compounds α‐tocopherol or Trolox, used at concentrations that reverse the oxidative stress‐induced toxicity, did not block the gliotoxicity specifically produced by t ‐PDC in the presence of D‐APV. The nontransportable glutamate uptake inhibitor DL‐threo‐β‐benzyloxyaspartate (TBOA) elicited cell death only in mature, but not in immature, hippocampal cultures. The TBOA toxic effect was dose dependent and reached a plateau at 100 μM in 23‐DIV cultures. About 50% of the cell population died. TBOA affected essentially the neuronal population. D‐APV (250 μM) completely reversed this toxicity. It is concluded that nontransportable glutamate uptake inhibitors are neurotoxic via overactivation of NMDA receptors, whereas transportable glutamate uptake inhibitors induce both an NMDA‐dependent neurotoxicity and an NMDA‐ and oxidative stress‐independent gliotoxicity, but only in mature hippocampal cultures. © 2005 Wiley‐Liss, Inc." @default.
• W2028005190 created "2016-06-24" @default.
• W2028005190 creator A5016114671 @default.
• W2028005190 creator A5029930504 @default.
• W2028005190 creator A5035932556 @default.
• W2028005190 creator A5037929703 @default.
• W2028005190 creator A5082292962 @default.
• W2028005190 creator A5090347969 @default.
• W2028005190 date "2005-06-01" @default.
• W2028005190 modified "2023-10-17" @default.
• W2028005190 title "Gliotoxicity in hippocampal cultures is induced by transportable, but not by nontransportable, glutamate uptake inhibitors" @default.
• W2028005190 cites W1486365342 @default.
• W2028005190 cites W1533853049 @default.
• W2028005190 cites W1573662382 @default.
• W2028005190 cites W1585639756 @default.
• W2028005190 cites W1629378997 @default.
• W2028005190 cites W1874574108 @default.
• W2028005190 cites W1900227502 @default.
• W2028005190 cites W1910864442 @default.
• W2028005190 cites W1947475203 @default.
• W2028005190 cites W1965902234 @default.
• W2028005190 cites W1966004273 @default.
• W2028005190 cites W1976754780 @default.
• W2028005190 cites W1976955003 @default.
• W2028005190 cites W1977976400 @default.
• W2028005190 cites W1979363543 @default.
• W2028005190 cites W1982888478 @default.
• W2028005190 cites W1986194193 @default.
• W2028005190 cites W1990969488 @default.
• W2028005190 cites W1992193294 @default.
• W2028005190 cites W1995731977 @default.
• W2028005190 cites W1999997324 @default.
• W2028005190 cites W2003410399 @default.
• W2028005190 cites W2003640569 @default.
• W2028005190 cites W2006376420 @default.
• W2028005190 cites W2008189718 @default.
• W2028005190 cites W2008321258 @default.
• W2028005190 cites W2008911826 @default.
• W2028005190 cites W2009295592 @default.
• W2028005190 cites W2016640140 @default.
• W2028005190 cites W2019031297 @default.
• W2028005190 cites W2031048328 @default.
• W2028005190 cites W2042550512 @default.
• W2028005190 cites W2047616247 @default.
• W2028005190 cites W2050746675 @default.
• W2028005190 cites W2051344987 @default.
• W2028005190 cites W2058948754 @default.
• W2028005190 cites W2065929873 @default.
• W2028005190 cites W2067587217 @default.
• W2028005190 cites W2072078981 @default.
• W2028005190 cites W2084250676 @default.
• W2028005190 cites W2087268155 @default.
• W2028005190 cites W2087948548 @default.
• W2028005190 cites W2094996078 @default.
• W2028005190 cites W2096675020 @default.
• W2028005190 cites W2104946318 @default.
• W2028005190 cites W2110653553 @default.
• W2028005190 cites W2121726351 @default.
• W2028005190 cites W2121792692 @default.
• W2028005190 cites W2126033464 @default.
• W2028005190 cites W2128744963 @default.
• W2028005190 cites W2129966883 @default.
• W2028005190 cites W2130294938 @default.
• W2028005190 cites W2155760865 @default.
• W2028005190 cites W2157853053 @default.
• W2028005190 cites W2158500293 @default.
• W2028005190 cites W2160228434 @default.
• W2028005190 cites W2160644313 @default.
• W2028005190 cites W2163314018 @default.
• W2028005190 cites W2163431685 @default.
• W2028005190 cites W2403978899 @default.
• W2028005190 cites W4210979710 @default.
• W2028005190 doi "https://doi.org/10.1002/jnr.20557" @default.
• W2028005190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15931685" @default.
• W2028005190 hasPublicationYear "2005" @default.
• W2028005190 type Work @default.
• W2028005190 sameAs 2028005190 @default.
• W2028005190 citedByCount "12" @default.
• W2028005190 countsByYear W20280051902012 @default.
• W2028005190 countsByYear W20280051902015 @default.
• W2028005190 crossrefType "journal-article" @default.
• W2028005190 hasAuthorship W2028005190A5016114671 @default.
• W2028005190 hasAuthorship W2028005190A5029930504 @default.
• W2028005190 hasAuthorship W2028005190A5035932556 @default.
• W2028005190 hasAuthorship W2028005190A5037929703 @default.
• W2028005190 hasAuthorship W2028005190A5082292962 @default.
• W2028005190 hasAuthorship W2028005190A5090347969 @default.
• W2028005190 hasConcept C134018914 @default.
• W2028005190 hasConcept C148762608 @default.
• W2028005190 hasConcept C170493617 @default.
• W2028005190 hasConcept C178790620 @default.
• W2028005190 hasConcept C185592680 @default.
• W2028005190 hasConcept C190283241 @default.
• W2028005190 hasConcept C2776151105 @default.
• W2028005190 hasConcept C2778740566 @default.
• W2028005190 hasConcept C2779491297 @default.
• W2028005190 hasConcept C2780358027 @default.
• W2028005190 hasConcept C2781012912 @default.

• next