Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028007585> ?p ?o ?g. }
- W2028007585 abstract "Advancing age and loss of bone mass and strength are closely linked. Elevated osteoblast and osteocyte apoptosis and decreased osteoblast number characterize the age-related skeletal changes in humans and rodents. Similar to other tissues, oxidative stress increases in bone with age. This article reviews current knowledge on the effects of the aging process on bone and its cellular constituents, with particular emphasis on the role of reactive oxygen species (ROS). FoxOs, sirtuins and the p53/p66shc signaling cascade alter osteoblast number and bone formation via ROS-dependent and -independent mechanisms. Specifically, activation of the p53/p66shc signaling increases osteoblast/osteocyte apoptosis in the aged skeleton and decreases bone mass. FoxO activation in osteoblasts prevents oxidative stress to preserve skeletal homeostasis. However, while defending against stress FoxOs bind to β-catenin and attenuate Wnt/T-cell cell factor transcriptional activity and osteoblast generation. Thus, pathways that impact longevity and several diseases of ageing might also contribute to age-related osteoporosis." @default.
- W2028007585 created "2016-06-24" @default.
- W2028007585 creator A5073329033 @default.
- W2028007585 date "2012-07-04" @default.
- W2028007585 modified "2023-10-13" @default.
- W2028007585 title "Aging mechanisms in bone" @default.
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- W2028007585 doi "https://doi.org/10.1038/bonekey.2012.102" @default.
- W2028007585 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3659822" @default.
- W2028007585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23705067" @default.