FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028013351> ?p ?o ?g. }

• W2028013351 endingPage "331" @default.
• W2028013351 startingPage "325" @default.
• W2028013351 abstract "Aging and short photoperiod exposure both induce similar long-term changes in circadian rhythms, including alterations in the timing and the amplitude of rhythms. Furthermore, these chronic conditions affect the function of the circadian pacemaker in the suprachiasmatic nuclei (SCN) by altering rhythmic expression of neuropeptide messenger RNAs (mRNAs). Because GABA modulates SCN neuronal activity, and GABAergic neurons innervate peptidergic neurons in the SCN, the present study investigated whether photoperiod or aging affect the expression of mRNA for GAD67, the enzyme responsible for regulating the tonic levels of GABA. As a control for regional specificity, the reticular thalamic nucleus (RTN) was also examined. In situ hybridization for GAD67 mRNA was performed on brain sections derived from Siberian hamsters exposed to a long day or a short day photoperiod for 15 days, and on brain sections from young (3–4 months old) and old (12–17 months old) Syrian hamsters exposed to a long photoperiod. The results showed that photoperiod and aging have different effects on GAD67 mRNA expression. Exposure to short day photoperiod significantly increased GAD67 mRNA expression in both the SCN and RTN of Siberian hamsters, while aging significantly decreased GAD67 mRNA expression in the RTN of Syrian hamsters but had no effect on GAD67 mRNA expression in the SCN. These findings suggest that modulation of GAD67 mRNA expression in the SCN is associated with photoperiodic regulation of neuropeptide mRNA expression, but is not a common mechanism for chronic regulation of circadian rhythms. Also, GAD67 mRNA expression in the RTN is differentially affected by photoperiod and aging." @default.
• W2028013351 created "2016-06-24" @default.
• W2028013351 creator A5076706012 @default.
• W2028013351 creator A5084126375 @default.
• W2028013351 date "1999-08-01" @default.
• W2028013351 modified "2023-09-27" @default.
• W2028013351 title "Aging and photoperiod regulate glutamic acid decarboxylase67 messenger RNA expression" @default.
• W2028013351 cites W118335968 @default.
• W2028013351 cites W1510072837 @default.
• W2028013351 cites W1968059634 @default.
• W2028013351 cites W1972456243 @default.
• W2028013351 cites W1982260519 @default.
• W2028013351 cites W1985280777 @default.
• W2028013351 cites W1987223615 @default.
• W2028013351 cites W1989123406 @default.
• W2028013351 cites W1990636704 @default.
• W2028013351 cites W1995799192 @default.
• W2028013351 cites W1998116616 @default.
• W2028013351 cites W1999713747 @default.
• W2028013351 cites W2001711337 @default.
• W2028013351 cites W2003070982 @default.
• W2028013351 cites W2004042726 @default.
• W2028013351 cites W2009914302 @default.
• W2028013351 cites W2012500875 @default.
• W2028013351 cites W2012917024 @default.
• W2028013351 cites W2014161453 @default.
• W2028013351 cites W2016187658 @default.
• W2028013351 cites W2017067141 @default.
• W2028013351 cites W2018770706 @default.
• W2028013351 cites W2020694953 @default.
• W2028013351 cites W2023286290 @default.
• W2028013351 cites W2023848782 @default.
• W2028013351 cites W2038213916 @default.
• W2028013351 cites W2044993718 @default.
• W2028013351 cites W2047678578 @default.
• W2028013351 cites W2053811617 @default.
• W2028013351 cites W2054154775 @default.
• W2028013351 cites W2067011924 @default.
• W2028013351 cites W2068420002 @default.
• W2028013351 cites W2071361120 @default.
• W2028013351 cites W2078660236 @default.
• W2028013351 cites W2079723292 @default.
• W2028013351 cites W2088211128 @default.
• W2028013351 cites W2091648102 @default.
• W2028013351 cites W2092246706 @default.
• W2028013351 cites W2092719147 @default.
• W2028013351 cites W2092820672 @default.
• W2028013351 cites W2117860217 @default.
• W2028013351 cites W2119206896 @default.
• W2028013351 cites W2136742543 @default.
• W2028013351 doi "https://doi.org/10.1016/s0169-328x(99)00206-5" @default.
• W2028013351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10521586" @default.
• W2028013351 hasPublicationYear "1999" @default.
• W2028013351 type Work @default.
• W2028013351 sameAs 2028013351 @default.
• W2028013351 citedByCount "10" @default.
• W2028013351 countsByYear W20280133512014 @default.
• W2028013351 countsByYear W20280133512015 @default.
• W2028013351 countsByYear W20280133512019 @default.
• W2028013351 crossrefType "journal-article" @default.
• W2028013351 hasAuthorship W2028013351A5076706012 @default.
• W2028013351 hasAuthorship W2028013351A5084126375 @default.
• W2028013351 hasConcept C104317684 @default.
• W2028013351 hasConcept C105580179 @default.
• W2028013351 hasConcept C121446783 @default.
• W2028013351 hasConcept C126322002 @default.
• W2028013351 hasConcept C134018914 @default.
• W2028013351 hasConcept C144027150 @default.
• W2028013351 hasConcept C17077164 @default.
• W2028013351 hasConcept C181199279 @default.
• W2028013351 hasConcept C2778575167 @default.
• W2028013351 hasConcept C2779177108 @default.
• W2028013351 hasConcept C2779317972 @default.
• W2028013351 hasConcept C55493867 @default.
• W2028013351 hasConcept C55969652 @default.
• W2028013351 hasConcept C71924100 @default.
• W2028013351 hasConcept C86803240 @default.
• W2028013351 hasConcept C9497952 @default.
• W2028013351 hasConceptScore W2028013351C104317684 @default.
• W2028013351 hasConceptScore W2028013351C105580179 @default.
• W2028013351 hasConceptScore W2028013351C121446783 @default.
• W2028013351 hasConceptScore W2028013351C126322002 @default.
• W2028013351 hasConceptScore W2028013351C134018914 @default.
• W2028013351 hasConceptScore W2028013351C144027150 @default.
• W2028013351 hasConceptScore W2028013351C17077164 @default.
• W2028013351 hasConceptScore W2028013351C181199279 @default.
• W2028013351 hasConceptScore W2028013351C2778575167 @default.
• W2028013351 hasConceptScore W2028013351C2779177108 @default.
• W2028013351 hasConceptScore W2028013351C2779317972 @default.
• W2028013351 hasConceptScore W2028013351C55493867 @default.
• W2028013351 hasConceptScore W2028013351C55969652 @default.
• W2028013351 hasConceptScore W2028013351C71924100 @default.
• W2028013351 hasConceptScore W2028013351C86803240 @default.
• W2028013351 hasConceptScore W2028013351C9497952 @default.
• W2028013351 hasIssue "2" @default.
• W2028013351 hasLocation W20280133511 @default.
• W2028013351 hasLocation W20280133512 @default.
• W2028013351 hasOpenAccess W2028013351 @default.

• next