Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028015113> ?p ?o ?g. }
- W2028015113 endingPage "57" @default.
- W2028015113 startingPage "48" @default.
- W2028015113 abstract "Cardiotrophin-1 (CTF1) has been reported to act as a trophic factor for a few neurons, such as sensory, cholinergic, dopaminergic, motor and cortical neurons. Studies have indicated that CTF1 delays degenerative disease progression in motor neuron disease. However, little is known about the effects of CTF1 on degenerative disease in the brain. We have shown that expression of CTF1 is strongly down-regulated in the brain of the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease (AD). Transgenic mice with brain tissue-specific CTF1 expression alone or in combination with APPswe/PS1dE9 transgenic mice were produced to study the effects of CTF1 on AD. CTF1 expressing APPswe/PS1dE9 transgenic mice exhibited improvements in learning and memory, less severe abnormalities in locomotor activity, reduced scattered senile plaques and ameliorated disturbances of brain energy metabolism compared to APPswe/PS1dE9 transgenic mice. Furthermore, CTF1 inhibited the activity of glycogen synthase kinase-3β (GSK-3β) in SH-SY5Y cell line and in the brain tissues of APPswe/PS1dE9 transgenic mice. The transgenic expression of CTF1 compensated for the loss of CTF1 expression and brought about a marked improvement on cognitive functioning in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease, suggesting that the inhibition of GSK-3β activity might play an important role." @default.
- W2028015113 created "2016-06-24" @default.
- W2028015113 creator A5017640036 @default.
- W2028015113 creator A5024385167 @default.
- W2028015113 creator A5033498789 @default.
- W2028015113 creator A5051153879 @default.
- W2028015113 creator A5051449882 @default.
- W2028015113 creator A5056246750 @default.
- W2028015113 creator A5073568638 @default.
- W2028015113 creator A5087664421 @default.
- W2028015113 date "2013-06-01" @default.
- W2028015113 modified "2023-10-18" @default.
- W2028015113 title "Cardiotrophin-1 (CTF1) ameliorates glucose-uptake defects and improves memory and learning deficits in a transgenic mouse model of Alzheimer's disease" @default.
- W2028015113 cites W146465976 @default.
- W2028015113 cites W1522806115 @default.
- W2028015113 cites W1857574091 @default.
- W2028015113 cites W1857742407 @default.
- W2028015113 cites W1968965662 @default.
- W2028015113 cites W1970293963 @default.
- W2028015113 cites W1974392986 @default.
- W2028015113 cites W1980542913 @default.
- W2028015113 cites W1981654394 @default.
- W2028015113 cites W1986733770 @default.
- W2028015113 cites W1988453006 @default.
- W2028015113 cites W1990867963 @default.
- W2028015113 cites W1991758365 @default.
- W2028015113 cites W1995341268 @default.
- W2028015113 cites W1996032125 @default.
- W2028015113 cites W1997177821 @default.
- W2028015113 cites W1999710695 @default.
- W2028015113 cites W2003721045 @default.
- W2028015113 cites W2005719973 @default.
- W2028015113 cites W2009081853 @default.
- W2028015113 cites W2012620585 @default.
- W2028015113 cites W2013155074 @default.
- W2028015113 cites W2018865756 @default.
- W2028015113 cites W2021044023 @default.
- W2028015113 cites W2031102482 @default.
- W2028015113 cites W2031451711 @default.
- W2028015113 cites W2032885546 @default.
- W2028015113 cites W2032960831 @default.
- W2028015113 cites W2036074343 @default.
- W2028015113 cites W2037755687 @default.
- W2028015113 cites W2038521086 @default.
- W2028015113 cites W2038727770 @default.
- W2028015113 cites W2039182476 @default.
- W2028015113 cites W2039229967 @default.
- W2028015113 cites W2039266320 @default.
- W2028015113 cites W2041833819 @default.
- W2028015113 cites W2047804089 @default.
- W2028015113 cites W2052104903 @default.
- W2028015113 cites W2053791137 @default.
- W2028015113 cites W2054183594 @default.
- W2028015113 cites W2055753122 @default.
- W2028015113 cites W2057791111 @default.
- W2028015113 cites W2058221507 @default.
- W2028015113 cites W2062064987 @default.
- W2028015113 cites W2069270713 @default.
- W2028015113 cites W2070997349 @default.
- W2028015113 cites W2072229087 @default.
- W2028015113 cites W2076531205 @default.
- W2028015113 cites W2077224993 @default.
- W2028015113 cites W2079206376 @default.
- W2028015113 cites W2080274663 @default.
- W2028015113 cites W2082446434 @default.
- W2028015113 cites W2088946660 @default.
- W2028015113 cites W2094133290 @default.
- W2028015113 cites W2095552729 @default.
- W2028015113 cites W2099143291 @default.
- W2028015113 cites W2101966650 @default.
- W2028015113 cites W2101991516 @default.
- W2028015113 cites W2115474152 @default.
- W2028015113 cites W2125657871 @default.
- W2028015113 cites W2129479063 @default.
- W2028015113 cites W2129920443 @default.
- W2028015113 cites W2133459825 @default.
- W2028015113 cites W2135654319 @default.
- W2028015113 cites W2138552466 @default.
- W2028015113 cites W2138948991 @default.
- W2028015113 cites W2142220223 @default.
- W2028015113 cites W2146188406 @default.
- W2028015113 cites W2146769188 @default.
- W2028015113 cites W2149863873 @default.
- W2028015113 cites W2152446053 @default.
- W2028015113 cites W2159538597 @default.
- W2028015113 cites W2163319886 @default.
- W2028015113 cites W2167132627 @default.
- W2028015113 cites W2168489336 @default.
- W2028015113 cites W2168493882 @default.
- W2028015113 cites W2169516583 @default.
- W2028015113 cites W2170622555 @default.
- W2028015113 cites W2171776741 @default.
- W2028015113 cites W2738397984 @default.
- W2028015113 cites W4376849741 @default.
- W2028015113 cites W62299013 @default.
- W2028015113 doi "https://doi.org/10.1016/j.pbb.2013.03.003" @default.
- W2028015113 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23541490" @default.
- W2028015113 hasPublicationYear "2013" @default.