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• W2028016411 abstract "We investigated the β-adrenoceptor subtypes mediating ureteral relaxation in rats, rabbits and dogs. The relaxing effects of β-adrenoceptor agonists were evaluated on KCl-induced ureteral contractions. The rank order of potency of the catecholamines tested was isoprenaline>noradrenaline>adrenaline in rat ureter; isoprenaline>adrenaline>noradrenaline in rabbit ureter; only isoprenaline was effective in canine tissues. The β1-adrenoceptor agonist, dobutamine, produced relaxation of rat ureter. The β2-adrenoceptor agonist, procaterol, produced more significant relaxation of rabbit ureter than did dobutamine. CL-316243 [(R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethylamino]propyl]-1,3-benzodioxole-2,2-dicarboxylate] and CGP-12177A [(±)[4-[3[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-1,3-dihydro-2H-benzimidazol-2-one hydrochloride], β3-adrenoceptor agonists, were more effective in relaxing canine ureter than were dobutamine and procaterol. Isoprenaline-induced relaxation was antagonized by a β1-adrenoceptor antagonist, CGP-20712A [2-hydroxy-5(2-((2-hydroxy-3-(4-((1-methyl-4-trifluoromethyl)1H-imidazole-2-yl)phenoxy)propyl)amino)ethoxy)-benzamide monomethane sulphonate], in rats and by a β2-adrenoceptor antagonist, ICI-118,551 [(±)-1-[(2,3-dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride], in rabbits. The non-selective β-adrenoceptor antagonist, bupranolol, antagonized isoprenaline-induced relaxation in all species tested. In conclusion, β-adrenoceptor agonists may relax ureter by stimulating mainly β1-adrenoceptors in rats, β2-adrenoceptors in rabbits and mainly β3-adrenoceptors in dogs." @default.
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• W2028016411 date "1998-07-01" @default.
• W2028016411 modified "2023-10-18" @default.
• W2028016411 title "β-Adrenoceptor subtypes in the ureteral smooth muscle of rats, rabbits and dogs" @default.
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• W2028016411 doi "https://doi.org/10.1016/s0014-2999(98)00360-4" @default.
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