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• W2028016845 abstract "Entry into the cell cycle represents a fundamental step before generating an effector immune response. The relationship between the cell cycle and antigen-driven T cell response remains, however, poorly understood in virus infection, including HIV. We have identified a critical fraction of CD4+CD45RO+ memory T lymphocytes that express the Ki67 antigen in chronically HIV-infected patients. A high accumulation of Ki67 protein is detected in CD4+CD45RO+Ki67+ cells that are in the G1 phase of the cell cycle (92 ± 5 %) but not in S and G2 + M phases, in contrast to normal individuals. Of these cells, 20 – 60 % are spontaneously producing IL-2 and IFN-γ, unlike CD4+CD45RO+ that do not express Ki67. In addition, HIV-p24 antigen is detectable only in a small fraction CD4+Ki67+ cells. In conclusion, CD4+Ki67+ lymphocytes are circulating effector cells accumulated in the G1 phase of the cell cycle and may be involved in the immune surveillance during HIV infection." @default.
• W2028016845 created "2016-06-24" @default.
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• W2028016845 date "2000-12-01" @default.
• W2028016845 modified "2023-09-27" @default.
• W2028016845 title "CD4+Ki67+ lymphocytes in HIV-infected patients are effector T cells accumulated in the G1 phase of the cell cycle" @default.
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• W2028016845 doi "https://doi.org/10.1002/1521-4141(200012)30:12<3598::aid-immu3598>3.0.co;2-e" @default.
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