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- W2028026324 abstract "Reported is an intramolecular annulation of α-amino (alkynylphenyl)methylphosphonates to either 1,2-dihydroisoquinolin-1-ylphosphonates or to 2H-isoindol-1-ylphosphonates, depending on the choice of catalyst. The Lewis acid AgOTf (Method A) leads to the former product via an 6-endo cyclization, whereas the Pd(II) catalyst, Pd(PhCN)2Cl2 (Method B) leads to the latter product via a 5-exo cyclization. The factors affecting this regioselectivity were not addressed but may be speculated to be due to distinctly different coordination and cation stabilizing properties of Ag+ vs Pd+2. The starting material is accessible by a three-component coupling of aldehydes, amines, and diethyl phosphate catalyzed by Lewis acids (J. Wu et al. Org. Biomol. Chem. 2006, 4, 1663). The isoindole and isoquinoline products were obtained in moderate to excellent yields and the substrate scope was sufficiently studied. A lower catalyst loading resulted in lower yields of products." @default.
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- W2028026324 date "2007-11-07" @default.
- W2028026324 modified "2023-09-27" @default.
- W2028026324 title "Metal-Tuned Synthesis of Isoindolyl and Isoquinolinyl Phosphonates" @default.
- W2028026324 doi "https://doi.org/10.1055/s-2007-968977" @default.
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