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• W2028029496 abstract "While α-tocopherol's role as the major membrane antioxidant has been certain for decades, its membrane structural role is far less certain. We are interested in a possible involvement of α-tocopherol in helping to hold proposed polyunsaturated fatty acid (PUFA)-rich, non-raft, domains together. The experiments presented here to test this hypothesis include differential scanning calorimetry (DSC), cold temperature detergent extractions and isothermal titration calorimetry (ITC) studies on model bilayer membranes and detergent extractions on living cell membranes. The DSC experiments indicate that in model membranes composed of sphingomyelin (SM) and 1-palmtioyl-2-docosahexaenoylphosphatidylethanolamine (16:0-22:6PE), cholesterol has a stronger association with SM while α-tocopherol prefers the polyunsaturated PE. Triton X-100 extractions on the same model system confirm that cholesterol segregates with SM (detergent insoluble fraction) and α-tocopherol segregates with 16:0-22:6PE (detergent soluble fraction). Currently underway are ITC experiments that measure the partitioning of α-tocopherol between lipid vesicles to quantify the stronger affinity for polyunsaturated lipids, and detergent extractions on living lymphocytes, where once again cholesterol is shown to preferentially segregate with SM into raft fractions, to observe preferential segregation of α-tocopherol with PUFA into non-raft fractions." @default.
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• W2028029496 date "2010-01-01" @default.
• W2028029496 modified "2023-09-28" @default.
• W2028029496 title "α-Tocopherol and Polyunsaturated Fatty Acid Membrane Domians" @default.
• W2028029496 doi "https://doi.org/10.1016/j.bpj.2009.12.2672" @default.
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