FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W202803896> ?p ?o ?g. }

• W202803896 endingPage "76" @default.
• W202803896 startingPage "61" @default.
• W202803896 abstract "AbstractRobust animal models have come to the forefront of understanding GBM biology and cancer biology in general. Specifically, genetically engineered murine models or GEMs have provided a great deal of understanding in investigating the role of p21-Ras in GBM. Elevation of Ras activity is a molecular hallmark of GBM and is under intense investigation. Several animal models have been engineered to express mutant forms of Ras or aberrantly express receptors, which modulate Ras activity. Embryonic stem cell transgenesis is a key methodology in engineering these mice models and so is tissue-specific targeting. We highlight several advantages of using ES-cell mediated transgenesis to generate mouse models expressing activated Ras. These animal models have been crucial in studying GBM formation, identifying novel GBM tumor suppressor genes using retroviral gene-trapping and how Ras synergizes with other signaling pathways to give rise to GBM. Lastly these models can be useful in identifying the potential cell of origin in GBM.KeywordsEmbryonic Stem CellGlial Fibrillary Acidic ProteinInner Cell MassGATA6 ExpressionMalignant AstrocytomaThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
• W202803896 created "2016-06-24" @default.
• W202803896 creator A5019642270 @default.
• W202803896 creator A5050166774 @default.
• W202803896 creator A5056492340 @default.
• W202803896 date "2009-01-01" @default.
• W202803896 modified "2023-09-26" @default.
• W202803896 title "Transgenic Mouse Models of CNS Tumors: Using Genetically Engineered Murine Models to Study the Role of p21-Ras in Glioblastoma Multiforme" @default.
• W202803896 cites W1597871117 @default.
• W202803896 cites W1965641543 @default.
• W202803896 cites W1969030756 @default.
• W202803896 cites W1975693251 @default.
• W202803896 cites W1986138672 @default.
• W202803896 cites W1987047126 @default.
• W202803896 cites W1999658678 @default.
• W202803896 cites W2001544973 @default.
• W202803896 cites W2019181873 @default.
• W202803896 cites W2023291891 @default.
• W202803896 cites W2033525551 @default.
• W202803896 cites W2044378010 @default.
• W202803896 cites W2045899482 @default.
• W202803896 cites W2047814166 @default.
• W202803896 cites W2048439815 @default.
• W202803896 cites W2055561480 @default.
• W202803896 cites W2063816440 @default.
• W202803896 cites W2065189089 @default.
• W202803896 cites W2092806325 @default.
• W202803896 cites W2100553819 @default.
• W202803896 cites W2104917184 @default.
• W202803896 cites W2119037095 @default.
• W202803896 cites W2164789880 @default.
• W202803896 cites W2318059699 @default.
• W202803896 cites W2322386893 @default.
• W202803896 doi "https://doi.org/10.1007/978-1-60327-553-8_4" @default.
• W202803896 hasPublicationYear "2009" @default.
• W202803896 type Work @default.
• W202803896 sameAs 202803896 @default.
• W202803896 citedByCount "1" @default.
• W202803896 countsByYear W2028038962013 @default.
• W202803896 crossrefType "book-chapter" @default.
• W202803896 hasAuthorship W202803896A5019642270 @default.
• W202803896 hasAuthorship W202803896A5050166774 @default.
• W202803896 hasAuthorship W202803896A5056492340 @default.
• W202803896 hasConcept C102230213 @default.
• W202803896 hasConcept C104317684 @default.
• W202803896 hasConcept C111829913 @default.
• W202803896 hasConcept C141035611 @default.
• W202803896 hasConcept C145103041 @default.
• W202803896 hasConcept C2776194525 @default.
• W202803896 hasConcept C3019111730 @default.
• W202803896 hasConcept C502942594 @default.
• W202803896 hasConcept C51456166 @default.
• W202803896 hasConcept C519853106 @default.
• W202803896 hasConcept C54355233 @default.
• W202803896 hasConcept C70721500 @default.
• W202803896 hasConcept C73247094 @default.
• W202803896 hasConcept C86803240 @default.
• W202803896 hasConcept C87073359 @default.
• W202803896 hasConcept C95444343 @default.
• W202803896 hasConceptScore W202803896C102230213 @default.
• W202803896 hasConceptScore W202803896C104317684 @default.
• W202803896 hasConceptScore W202803896C111829913 @default.
• W202803896 hasConceptScore W202803896C141035611 @default.
• W202803896 hasConceptScore W202803896C145103041 @default.
• W202803896 hasConceptScore W202803896C2776194525 @default.
• W202803896 hasConceptScore W202803896C3019111730 @default.
• W202803896 hasConceptScore W202803896C502942594 @default.
• W202803896 hasConceptScore W202803896C51456166 @default.
• W202803896 hasConceptScore W202803896C519853106 @default.
• W202803896 hasConceptScore W202803896C54355233 @default.
• W202803896 hasConceptScore W202803896C70721500 @default.
• W202803896 hasConceptScore W202803896C73247094 @default.
• W202803896 hasConceptScore W202803896C86803240 @default.
• W202803896 hasConceptScore W202803896C87073359 @default.
• W202803896 hasConceptScore W202803896C95444343 @default.
• W202803896 hasLocation W2028038961 @default.
• W202803896 hasOpenAccess W202803896 @default.
• W202803896 hasPrimaryLocation W2028038961 @default.
• W202803896 hasRelatedWork W157719787 @default.
• W202803896 hasRelatedWork W163061879 @default.
• W202803896 hasRelatedWork W1976691387 @default.
• W202803896 hasRelatedWork W1976767260 @default.
• W202803896 hasRelatedWork W1989600825 @default.
• W202803896 hasRelatedWork W2010346256 @default.
• W202803896 hasRelatedWork W2014983255 @default.
• W202803896 hasRelatedWork W2029982530 @default.
• W202803896 hasRelatedWork W2062573656 @default.
• W202803896 hasRelatedWork W2063814011 @default.
• W202803896 hasRelatedWork W2066221064 @default.
• W202803896 hasRelatedWork W2163067316 @default.
• W202803896 hasRelatedWork W2177750764 @default.
• W202803896 hasRelatedWork W2469572482 @default.
• W202803896 hasRelatedWork W2475056980 @default.
• W202803896 hasRelatedWork W2883101927 @default.
• W202803896 hasRelatedWork W3034832281 @default.
• W202803896 hasRelatedWork W3048814571 @default.
• W202803896 hasRelatedWork W3161604550 @default.
• W202803896 hasRelatedWork W3177144045 @default.

• next