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• W2028041682 abstract "Three gastrointestinal factors influencing aspirin absorption have been selectively adjusted for quantitative measurement of their effect on the rate of salicylate absorption in humans and dogs. These are (a) gastric emptying, (b) aspirin dissolution rate, and (c) intragastric pH. Other factors such as tablet disintegration time, aspirin particle size, and intersubject variability have been eliminated or reduced where possible. The major portion of the salicylate in the blood during the first 20 minutes comes from the stomach. Impedance of gastric emptying by the use of atropine and placing the subjects in a left lateral position did not eliminate the higher plasma salicylate levels produced by the inclusion of the buffer antacids in aspirin tablets. The major effect of these antacids appears to be an acceleration of aspirin dissolution. This has been confirmed in this study by an in vivo demonstration of more rapid absorption from solutions of aspirin than from tablets. Aspirin in solution has a lower pH alone than with the inclusion of buffering antacids. Selective adjustment of the degree of aspirin and sodium salicylate ionization through the use of various buffers provided a method of study of the influence of intragastric pH on the rate of aspirin absorption. Support was obtained from dog and human studies in favor of the pH partition hypothesis that salicylates are absorbed more rapidly at low pH values. Three gastrointestinal factors influencing aspirin absorption have been selectively adjusted for quantitative measurement of their effect on the rate of salicylate absorption in humans and dogs. These are (a) gastric emptying, (b) aspirin dissolution rate, and (c) intragastric pH. Other factors such as tablet disintegration time, aspirin particle size, and intersubject variability have been eliminated or reduced where possible. The major portion of the salicylate in the blood during the first 20 minutes comes from the stomach. Impedance of gastric emptying by the use of atropine and placing the subjects in a left lateral position did not eliminate the higher plasma salicylate levels produced by the inclusion of the buffer antacids in aspirin tablets. The major effect of these antacids appears to be an acceleration of aspirin dissolution. This has been confirmed in this study by an in vivo demonstration of more rapid absorption from solutions of aspirin than from tablets. Aspirin in solution has a lower pH alone than with the inclusion of buffering antacids. Selective adjustment of the degree of aspirin and sodium salicylate ionization through the use of various buffers provided a method of study of the influence of intragastric pH on the rate of aspirin absorption. Support was obtained from dog and human studies in favor of the pH partition hypothesis that salicylates are absorbed more rapidly at low pH values." @default.
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• W2028041682 date "1964-02-01" @default.
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• W2028041682 title "Gastrointestinal Factors in Aspirin Absorption" @default.
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• W2028041682 doi "https://doi.org/10.1002/jps.2600530203" @default.
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