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- W2028045162 abstract "The fluoroalkane gases used to propel aerosols were toxic to the hearts of 34 mice, sensitizing them to asphyxiainduced sinus bradycardia, atrioventricular block, and T-waue depression. Cardiac sensitization was rapid, long-lasting, and lethal. It also occurred in rats and dogs. The propellants are postulated to possess a spectrum of cardiotoxic effects capable, in various species, of causing bradyarrhythmias, tachyarrhythmias, or myocardial depression. In humans the cardiac toxicity of aerosol propellants, particularly during asphyxia, may be a cause of sudden death in youths who turn on by inhaling propellants and in patients with asthma who make excessive use of bronchodilator aerosols. To a degree presently unknown, cardiac toxicity, including arrhythmias, due to propellant inhalation may be a potential hazard to frequent users of pressurized aerosol dispensers." @default.
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- W2028045162 date "1970-10-05" @default.
- W2028045162 modified "2023-10-09" @default.
- W2028045162 title "Cardiac Toxicity of Aerosol Propellants" @default.
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- W2028045162 doi "https://doi.org/10.1001/jama.1970.03180010023004" @default.
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