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- W2028049330 abstract "Background . Cardiac involvement in systemic sclerosis ( SSc) is controversial but theprimary disorder of microvasculature with diffuse arteriolar and capillary lesions couldprecede any fibrosis, thus causing ischemic dysfunction. Previous studies of coronaryflow velocity reserve (CFVR) have demonstrated that CFVR is impaired in patients withSSc. L-Propionylcarnitine( L-Pc) is a metabolic substance that exerts a beneficial effecton both microcirculation and myocite function. We tested the hypothesis that CFVR canbe early impaired in patients with SSc without cardiac involvement and whether CFVRcould improve after intravenous administration of L-Pc. Methods . We studied 11 females patients (6 with diffuse form and 5 with localized formof SSc) without clinical evidence of heart disease, mean age 54±11 years and 26 controlgroup patients, matched for age. We evaluated CFVR in the left anterior descending coronaryartery (LAD) with contrast Doppler echocardiography during adenosine infusion(140 µg/Kg/min in 5 minutes), before and after 15 minutes of administration of L-Pc ( 300mg intravenous in 5 minutes bolus). Results : In patients with SSc CFVR was impaired in comparison to the control grouppatients (2.56 ± 0.54 vs 3.29±0.52, p=0.0005). Furthermore, in patients with SSc afteradministration of L-Pc, CFVR increased from 2.56 ± 0.51 to 3.38±0.9, p=0.01. The peakdiastolic velocity in the LAD at rest, before and after L-Pc administration were not different(33.8 ±11 vs 28.5±8.6, p=ns). Conclusion . CFVR is early impaired in patients with SSc without clinical evidence ofheart disease. Acute administration of L-Pc exerts a beneficial effect on microvasculaturein patients with systemic sclerosis. Therefore, its potential after chronic administrationneeds to be evaluated." @default.
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- W2028049330 date "2004-03-01" @default.
- W2028049330 modified "2023-10-17" @default.
- W2028049330 title "1164-132 Effect of acute administration of L-propionylcarnitine on coronary flow velocity reserve in patients with systemic sclerosis" @default.
- W2028049330 doi "https://doi.org/10.1016/s0735-1097(04)90985-0" @default.
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