FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028078051> ?p ?o ?g. }

• W2028078051 endingPage "1832" @default.
• W2028078051 startingPage "1832" @default.
• W2028078051 abstract "Purpose.: The purpose of this study was to elucidate the pathophysiological process in primary cultured corneal fibroblasts (PCFs) from normal subjects and granular corneal dystrophy (GCD) II patients, by using cDNA microarrays. Methods.: PCFs were isolated from the corneas of normal subjects and GCD II patients who were heterozygous and homozygous for the TGFBI R124H mutation. RNA was isolated from each sample, and gene expression profiles were analyzed with a cDNA microarray consisting of approximately 29,000 genes. Cell adhesion assays were performed to confirm the functionality of the detected gene expression profiles. Results.: Twofold differences were detected in the expression of 555 genes between wild-type and homozygous GCD II PCFs. Of these, 319 genes were upregulated, and 236 genes were downregulated in the homozygous GCD II PCFs. The most abundant and consistent changes were observed in gene families encoding signal transduction pathways involving the TGF-β receptor– and integrin-mediated signaling, cell differentiation and proliferation, immune responses, cell adhesion, extracellular matrix (ECM) proteolytic enzymes, cell cycle, cytoskeletal organization, mitochondrial energy metabolism, collagen catabolism, response to wounding, response to oxidative stress, and the ubiquitin-mediated proteasomal degradation pathway. Cell adhesion assays demonstrated that heterozygous and homozygous GCD II PCFs strongly attached to collagen-I, collagen-IV, fibronectin, and laminin, compared with wild-type cells. Conclusions.: Alterations in the TGF-β receptor– and integrin-mediated signaling pathway may play a key role in GCD II pathophysiology. If the novel factors identified in this study are involved in GCD II pathogenesis, they could assist in designing further studies to elucidate specific mechanisms of this disease." @default.
• W2028078051 created "2016-06-24" @default.
• W2028078051 creator A5009316730 @default.
• W2028078051 creator A5010105077 @default.
• W2028078051 creator A5030362219 @default.
• W2028078051 creator A5032703829 @default.
• W2028078051 creator A5051121123 @default.
• W2028078051 creator A5051901421 @default.
• W2028078051 creator A5062228503 @default.
• W2028078051 creator A5072734871 @default.
• W2028078051 creator A5088140503 @default.
• W2028078051 date "2010-04-01" @default.
• W2028078051 modified "2023-10-16" @default.
• W2028078051 title "Involvement of TGF-β Receptor– and Integrin-Mediated Signaling Pathways in the Pathogenesis of Granular Corneal Dystrophy II" @default.
• W2028078051 cites W133363387 @default.
• W2028078051 cites W1524731504 @default.
• W2028078051 cites W1539442102 @default.
• W2028078051 cites W1544187591 @default.
• W2028078051 cites W1584637157 @default.
• W2028078051 cites W1600831053 @default.
• W2028078051 cites W1645365656 @default.
• W2028078051 cites W1890188140 @default.
• W2028078051 cites W1968535706 @default.
• W2028078051 cites W1968856524 @default.
• W2028078051 cites W1968900405 @default.
• W2028078051 cites W1972430281 @default.
• W2028078051 cites W1975794789 @default.
• W2028078051 cites W1984282769 @default.
• W2028078051 cites W1989316008 @default.
• W2028078051 cites W1991041575 @default.
• W2028078051 cites W1996775775 @default.
• W2028078051 cites W2008384111 @default.
• W2028078051 cites W2016574126 @default.
• W2028078051 cites W2022324102 @default.
• W2028078051 cites W2023531011 @default.
• W2028078051 cites W2026058763 @default.
• W2028078051 cites W2026215632 @default.
• W2028078051 cites W2031998212 @default.
• W2028078051 cites W2036634057 @default.
• W2028078051 cites W2039327092 @default.
• W2028078051 cites W2056693619 @default.
• W2028078051 cites W2060981595 @default.
• W2028078051 cites W2061445074 @default.
• W2028078051 cites W2064792002 @default.
• W2028078051 cites W2071757683 @default.
• W2028078051 cites W2077142274 @default.
• W2028078051 cites W2092338556 @default.
• W2028078051 cites W2140746826 @default.
• W2028078051 cites W2166474806 @default.
• W2028078051 cites W2316067769 @default.
• W2028078051 cites W92426398 @default.
• W2028078051 doi "https://doi.org/10.1167/iovs.09-4149" @default.
• W2028078051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19933198" @default.
• W2028078051 hasPublicationYear "2010" @default.
• W2028078051 type Work @default.
• W2028078051 sameAs 2028078051 @default.
• W2028078051 citedByCount "16" @default.
• W2028078051 countsByYear W20280780512014 @default.
• W2028078051 countsByYear W20280780512015 @default.
• W2028078051 countsByYear W20280780512016 @default.
• W2028078051 countsByYear W20280780512018 @default.
• W2028078051 countsByYear W20280780512020 @default.
• W2028078051 countsByYear W20280780512021 @default.
• W2028078051 countsByYear W20280780512022 @default.
• W2028078051 countsByYear W20280780512023 @default.
• W2028078051 crossrefType "journal-article" @default.
• W2028078051 hasAuthorship W2028078051A5009316730 @default.
• W2028078051 hasAuthorship W2028078051A5010105077 @default.
• W2028078051 hasAuthorship W2028078051A5030362219 @default.
• W2028078051 hasAuthorship W2028078051A5032703829 @default.
• W2028078051 hasAuthorship W2028078051A5051121123 @default.
• W2028078051 hasAuthorship W2028078051A5051901421 @default.
• W2028078051 hasAuthorship W2028078051A5062228503 @default.
• W2028078051 hasAuthorship W2028078051A5072734871 @default.
• W2028078051 hasAuthorship W2028078051A5088140503 @default.
• W2028078051 hasConcept C104317684 @default.
• W2028078051 hasConcept C1491633281 @default.
• W2028078051 hasConcept C150194340 @default.
• W2028078051 hasConcept C151166631 @default.
• W2028078051 hasConcept C153911025 @default.
• W2028078051 hasConcept C170493617 @default.
• W2028078051 hasConcept C189165786 @default.
• W2028078051 hasConcept C195687474 @default.
• W2028078051 hasConcept C2778615650 @default.
• W2028078051 hasConcept C2779814568 @default.
• W2028078051 hasConcept C54355233 @default.
• W2028078051 hasConcept C62478195 @default.
• W2028078051 hasConcept C85789140 @default.
• W2028078051 hasConcept C86492073 @default.
• W2028078051 hasConcept C86803240 @default.
• W2028078051 hasConcept C95444343 @default.
• W2028078051 hasConceptScore W2028078051C104317684 @default.
• W2028078051 hasConceptScore W2028078051C1491633281 @default.
• W2028078051 hasConceptScore W2028078051C150194340 @default.
• W2028078051 hasConceptScore W2028078051C151166631 @default.
• W2028078051 hasConceptScore W2028078051C153911025 @default.
• W2028078051 hasConceptScore W2028078051C170493617 @default.
• W2028078051 hasConceptScore W2028078051C189165786 @default.

• next