FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028078512> ?p ?o ?g. }

• W2028078512 endingPage "733" @default.
• W2028078512 startingPage "729" @default.
• W2028078512 abstract "Somatic point mutations provide glimpses into B‐cell histories, and mutation numbers generally correlate with antibody affinity. We recently proposed a model of human isotype function, based in part on mutation analysis, in which the dominant pathway of isotype switching involves B cells moving sequentially through the four immunoglobulin (Ig) G subclasses. This should result in predictable differences in affinity between isotypes, and this helps explain how different isotypes work together. The model built on analysis of rearranged immunoglobulin heavy chain sequences amplified from Papua New Guinean villagers, which showed highly significant differences in the mean number of V‐REGION mutations in sequences, associated with the different IgG subclasses. To determine whether this relationship between mutation levels and isotypes is a more general phenomenon, the present study was conducted in healthy, urban residents of Sydney, Australia. VDJ sequences were generated from eight individuals, using 454 pyrosequencing, from cells expressing all isotypes except IgD and IgE. This resulted in 35 118 unique, productive VDJ sequences for the study. The data confirm that VDJ genes associated with progressively more 3′ Ig heavy chain gamma (IGHG) constant region genes show increasing levels of point mutation. Mean V‐REGION mutations in IgA1 and IgA2 sequences were similar. Patterns of mutations also differed between isotypes. Despite their association with T‐independent responses, IgG2 sequences showed significantly more mutational evidence of antigen selection than other IgG isotypes. Antigen selection was also significantly higher in IgA2 than in IgA1 sequences, raising the possibility of a preferential switch pathway from IGHG2 to IGHA2 ." @default.
• W2028078512 created "2016-06-24" @default.
• W2028078512 creator A5003642180 @default.
• W2028078512 creator A5018874456 @default.
• W2028078512 creator A5069859112 @default.
• W2028078512 date "2014-06-10" @default.
• W2028078512 modified "2023-10-17" @default.
• W2028078512 title "Human immunoglobulin classes and subclasses show variability in VDJ gene mutation levels" @default.
• W2028078512 cites W1510119750 @default.
• W2028078512 cites W1539431222 @default.
• W2028078512 cites W1576921730 @default.
• W2028078512 cites W1607133945 @default.
• W2028078512 cites W1607182675 @default.
• W2028078512 cites W1680951199 @default.
• W2028078512 cites W1696337576 @default.
• W2028078512 cites W1965272893 @default.
• W2028078512 cites W1971041641 @default.
• W2028078512 cites W1974807325 @default.
• W2028078512 cites W1980628113 @default.
• W2028078512 cites W1991656907 @default.
• W2028078512 cites W1993150792 @default.
• W2028078512 cites W2005988541 @default.
• W2028078512 cites W2019525977 @default.
• W2028078512 cites W2020094108 @default.
• W2028078512 cites W2055443357 @default.
• W2028078512 cites W2060811951 @default.
• W2028078512 cites W2069185441 @default.
• W2028078512 cites W2106833014 @default.
• W2028078512 cites W2117172098 @default.
• W2028078512 cites W2129560853 @default.
• W2028078512 cites W2138067488 @default.
• W2028078512 cites W2163673566 @default.
• W2028078512 doi "https://doi.org/10.1038/icb.2014.44" @default.
• W2028078512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24913324" @default.
• W2028078512 hasPublicationYear "2014" @default.
• W2028078512 type Work @default.
• W2028078512 sameAs 2028078512 @default.
• W2028078512 citedByCount "73" @default.
• W2028078512 countsByYear W20280785122014 @default.
• W2028078512 countsByYear W20280785122015 @default.
• W2028078512 countsByYear W20280785122016 @default.
• W2028078512 countsByYear W20280785122017 @default.
• W2028078512 countsByYear W20280785122018 @default.
• W2028078512 countsByYear W20280785122019 @default.
• W2028078512 countsByYear W20280785122020 @default.
• W2028078512 countsByYear W20280785122021 @default.
• W2028078512 countsByYear W20280785122022 @default.
• W2028078512 countsByYear W20280785122023 @default.
• W2028078512 crossrefType "journal-article" @default.
• W2028078512 hasAuthorship W2028078512A5003642180 @default.
• W2028078512 hasAuthorship W2028078512A5018874456 @default.
• W2028078512 hasAuthorship W2028078512A5069859112 @default.
• W2028078512 hasConcept C104317684 @default.
• W2028078512 hasConcept C128526571 @default.
• W2028078512 hasConcept C137756551 @default.
• W2028078512 hasConcept C141105273 @default.
• W2028078512 hasConcept C153911025 @default.
• W2028078512 hasConcept C159654299 @default.
• W2028078512 hasConcept C176944494 @default.
• W2028078512 hasConcept C2777991845 @default.
• W2028078512 hasConcept C2778453870 @default.
• W2028078512 hasConcept C36394416 @default.
• W2028078512 hasConcept C48010095 @default.
• W2028078512 hasConcept C501734568 @default.
• W2028078512 hasConcept C542903549 @default.
• W2028078512 hasConcept C54355233 @default.
• W2028078512 hasConcept C86803240 @default.
• W2028078512 hasConcept C96007430 @default.
• W2028078512 hasConceptScore W2028078512C104317684 @default.
• W2028078512 hasConceptScore W2028078512C128526571 @default.
• W2028078512 hasConceptScore W2028078512C137756551 @default.
• W2028078512 hasConceptScore W2028078512C141105273 @default.
• W2028078512 hasConceptScore W2028078512C153911025 @default.
• W2028078512 hasConceptScore W2028078512C159654299 @default.
• W2028078512 hasConceptScore W2028078512C176944494 @default.
• W2028078512 hasConceptScore W2028078512C2777991845 @default.
• W2028078512 hasConceptScore W2028078512C2778453870 @default.
• W2028078512 hasConceptScore W2028078512C36394416 @default.
• W2028078512 hasConceptScore W2028078512C48010095 @default.
• W2028078512 hasConceptScore W2028078512C501734568 @default.
• W2028078512 hasConceptScore W2028078512C542903549 @default.
• W2028078512 hasConceptScore W2028078512C54355233 @default.
• W2028078512 hasConceptScore W2028078512C86803240 @default.
• W2028078512 hasConceptScore W2028078512C96007430 @default.
• W2028078512 hasIssue "8" @default.
• W2028078512 hasLocation W20280785121 @default.
• W2028078512 hasLocation W20280785122 @default.
• W2028078512 hasOpenAccess W2028078512 @default.
• W2028078512 hasPrimaryLocation W20280785121 @default.
• W2028078512 hasRelatedWork W1160163724 @default.
• W2028078512 hasRelatedWork W1604135620 @default.
• W2028078512 hasRelatedWork W2002485931 @default.
• W2028078512 hasRelatedWork W2079957181 @default.
• W2028078512 hasRelatedWork W2105432925 @default.
• W2028078512 hasRelatedWork W2154760236 @default.
• W2028078512 hasRelatedWork W2211612344 @default.
• W2028078512 hasRelatedWork W2588429898 @default.
• W2028078512 hasRelatedWork W4313387811 @default.

• next