Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028082845> ?p ?o ?g. }
- W2028082845 endingPage "1630" @default.
- W2028082845 startingPage "1623" @default.
- W2028082845 abstract "Helminth parasites are known to alter host immune responses and the responsible molecules are a potential source of biological immunoadjuvants. Previously, we have reported strong Th-2 type immunomodulatory properties of Taenia crassiceps glycans. In this study, we report interferon-gamma (IFN-gamma) stimulatory activity of fractionated Taenia glycans and Lewis sugars with comparable glycan composition. Our data show that Taenia glycans and Lewis X pentasaccharide are potent stimulators of the Th-1 type cytokine IFN-gamma. We postulate that the terminal beta-(1-4)-galactose residue in Lewis X is associated with IFN-gamma stimulation from naive BALB/c mouse spleen and peritoneal exudate cells. Antibodies to toll-like receptors (TLRs) inhibited the Lewis X-induced IFN-gamma secretion. Lewis X up-regulated the expression of NF-kappaB p65 from naive spleen cells and IFN-gamma transcription in peritoneal exudate cells. These data demonstrate the ability of Lewis type helminth glycans to modulate host responses in a Th-1 direction via NF-kappaB p65, IFN-gamma and macrophage TLRs." @default.
- W2028082845 created "2016-06-24" @default.
- W2028082845 creator A5074992620 @default.
- W2028082845 creator A5090339699 @default.
- W2028082845 date "2007-03-01" @default.
- W2028082845 modified "2023-09-25" @default.
- W2028082845 title "Induction of interferon-γ by Taenia crassiceps glycans and Lewis sugars in naive BALB/c spleen and peritoneal exudate cells" @default.
- W2028082845 cites W1501020757 @default.
- W2028082845 cites W1656812865 @default.
- W2028082845 cites W1665471078 @default.
- W2028082845 cites W1841461077 @default.
- W2028082845 cites W1950874980 @default.
- W2028082845 cites W1974118593 @default.
- W2028082845 cites W1974720495 @default.
- W2028082845 cites W1975602003 @default.
- W2028082845 cites W1979191333 @default.
- W2028082845 cites W1987160189 @default.
- W2028082845 cites W1988128973 @default.
- W2028082845 cites W1989978175 @default.
- W2028082845 cites W1995702637 @default.
- W2028082845 cites W1995778103 @default.
- W2028082845 cites W1998094992 @default.
- W2028082845 cites W1999062828 @default.
- W2028082845 cites W2005842006 @default.
- W2028082845 cites W2021368507 @default.
- W2028082845 cites W2034556265 @default.
- W2028082845 cites W2038073973 @default.
- W2028082845 cites W2042480993 @default.
- W2028082845 cites W2043789134 @default.
- W2028082845 cites W2045114633 @default.
- W2028082845 cites W2056443302 @default.
- W2028082845 cites W2059865389 @default.
- W2028082845 cites W2085747741 @default.
- W2028082845 cites W2087734502 @default.
- W2028082845 cites W2097456894 @default.
- W2028082845 cites W2097515362 @default.
- W2028082845 cites W2121215144 @default.
- W2028082845 cites W2123863820 @default.
- W2028082845 cites W2127092918 @default.
- W2028082845 cites W2133231180 @default.
- W2028082845 cites W2136490822 @default.
- W2028082845 cites W2139235644 @default.
- W2028082845 cites W2161504113 @default.
- W2028082845 cites W2162520457 @default.
- W2028082845 cites W2166417236 @default.
- W2028082845 cites W2169993463 @default.
- W2028082845 cites W4231694748 @default.
- W2028082845 cites W4243182832 @default.
- W2028082845 cites W4246991801 @default.
- W2028082845 cites W2135598967 @default.
- W2028082845 doi "https://doi.org/10.1016/j.molimm.2006.08.019" @default.
- W2028082845 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17034862" @default.
- W2028082845 hasPublicationYear "2007" @default.
- W2028082845 type Work @default.
- W2028082845 sameAs 2028082845 @default.
- W2028082845 citedByCount "20" @default.
- W2028082845 countsByYear W20280828452012 @default.
- W2028082845 countsByYear W20280828452013 @default.
- W2028082845 countsByYear W20280828452014 @default.
- W2028082845 countsByYear W20280828452015 @default.
- W2028082845 countsByYear W20280828452020 @default.
- W2028082845 countsByYear W20280828452021 @default.
- W2028082845 countsByYear W20280828452022 @default.
- W2028082845 crossrefType "journal-article" @default.
- W2028082845 hasAuthorship W2028082845A5074992620 @default.
- W2028082845 hasAuthorship W2028082845A5090339699 @default.
- W2028082845 hasConcept C108625454 @default.
- W2028082845 hasConcept C153911025 @default.
- W2028082845 hasConcept C165901193 @default.
- W2028082845 hasConcept C185592680 @default.
- W2028082845 hasConcept C203014093 @default.
- W2028082845 hasConcept C206212055 @default.
- W2028082845 hasConcept C2775963980 @default.
- W2028082845 hasConcept C2778573061 @default.
- W2028082845 hasConcept C2779452502 @default.
- W2028082845 hasConcept C2780841837 @default.
- W2028082845 hasConcept C2780931953 @default.
- W2028082845 hasConcept C59822182 @default.
- W2028082845 hasConcept C86803240 @default.
- W2028082845 hasConcept C8891405 @default.
- W2028082845 hasConcept C89423630 @default.
- W2028082845 hasConceptScore W2028082845C108625454 @default.
- W2028082845 hasConceptScore W2028082845C153911025 @default.
- W2028082845 hasConceptScore W2028082845C165901193 @default.
- W2028082845 hasConceptScore W2028082845C185592680 @default.
- W2028082845 hasConceptScore W2028082845C203014093 @default.
- W2028082845 hasConceptScore W2028082845C206212055 @default.
- W2028082845 hasConceptScore W2028082845C2775963980 @default.
- W2028082845 hasConceptScore W2028082845C2778573061 @default.
- W2028082845 hasConceptScore W2028082845C2779452502 @default.
- W2028082845 hasConceptScore W2028082845C2780841837 @default.
- W2028082845 hasConceptScore W2028082845C2780931953 @default.
- W2028082845 hasConceptScore W2028082845C59822182 @default.
- W2028082845 hasConceptScore W2028082845C86803240 @default.
- W2028082845 hasConceptScore W2028082845C8891405 @default.
- W2028082845 hasConceptScore W2028082845C89423630 @default.
- W2028082845 hasIssue "7" @default.
- W2028082845 hasLocation W20280828451 @default.