Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028083875> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2028083875 abstract "Cryptococcal meningitis (CM) is a common disease in resource-challenged settings, with a high mortality within weeks of disease onset. Mortality remains high with current treatments, so more effective interventions are needed to decrease mortality. There has been interest in using the outcome assessment of quantification of fungus from cerebrospinal fluid as a replacement (surrogate) endpoint for all-cause mortality (ACM) as a means of decreasing sample size in randomized clinical trials in CM. To evaluate a biomarker as a potential surrogate endpoint to replace ACM requires several steps. This paper discusses the issues of determining whether the context of a disease is one where a potential surrogate endpoint is rational, the types of outcome assessments that might qualify as potential surrogates, and the process for evaluation of the evidence that a chosen biomarker is a valid replacement for ACM in the given context of use. We then apply those principles to the context of randomized clinical trials of CM." @default.
- W2028083875 created "2016-06-24" @default.
- W2028083875 creator A5045602329 @default.
- W2028083875 creator A5089434357 @default.
- W2028083875 date "2014-07-29" @default.
- W2028083875 modified "2023-09-24" @default.
- W2028083875 title "Outcome Assessments in Clinical Trials of Cryptococcal Meningitis: Considerations on Use of Early Fungicidal Activity as a Potential Surrogate Endpoint for All-Cause Mortality" @default.
- W2028083875 cites W1213581300 @default.
- W2028083875 cites W1590018298 @default.
- W2028083875 cites W1997032499 @default.
- W2028083875 cites W1997771894 @default.
- W2028083875 cites W2028590696 @default.
- W2028083875 cites W2052416660 @default.
- W2028083875 cites W2054253853 @default.
- W2028083875 cites W2073100197 @default.
- W2028083875 cites W2078110114 @default.
- W2028083875 cites W2079513681 @default.
- W2028083875 cites W2080675410 @default.
- W2028083875 cites W2096006098 @default.
- W2028083875 cites W2132441677 @default.
- W2028083875 cites W2133742555 @default.
- W2028083875 cites W2136955446 @default.
- W2028083875 cites W2143732246 @default.
- W2028083875 cites W2143928313 @default.
- W2028083875 cites W2154894130 @default.
- W2028083875 cites W2331249764 @default.
- W2028083875 cites W3146780943 @default.
- W2028083875 cites W91108901 @default.
- W2028083875 doi "https://doi.org/10.1007/s40506-014-0026-0" @default.
- W2028083875 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4545574" @default.
- W2028083875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26306077" @default.
- W2028083875 hasPublicationYear "2014" @default.
- W2028083875 type Work @default.
- W2028083875 sameAs 2028083875 @default.
- W2028083875 citedByCount "2" @default.
- W2028083875 countsByYear W20280838752016 @default.
- W2028083875 countsByYear W20280838752017 @default.
- W2028083875 crossrefType "journal-article" @default.
- W2028083875 hasAuthorship W2028083875A5045602329 @default.
- W2028083875 hasAuthorship W2028083875A5089434357 @default.
- W2028083875 hasBestOaLocation W20280838752 @default.
- W2028083875 hasConcept C126322002 @default.
- W2028083875 hasConcept C141341695 @default.
- W2028083875 hasConcept C151730666 @default.
- W2028083875 hasConcept C168563851 @default.
- W2028083875 hasConcept C177713679 @default.
- W2028083875 hasConcept C185592680 @default.
- W2028083875 hasConcept C203092338 @default.
- W2028083875 hasConcept C2779343474 @default.
- W2028083875 hasConcept C2781197716 @default.
- W2028083875 hasConcept C535046627 @default.
- W2028083875 hasConcept C55493867 @default.
- W2028083875 hasConcept C71924100 @default.
- W2028083875 hasConcept C86803240 @default.
- W2028083875 hasConceptScore W2028083875C126322002 @default.
- W2028083875 hasConceptScore W2028083875C141341695 @default.
- W2028083875 hasConceptScore W2028083875C151730666 @default.
- W2028083875 hasConceptScore W2028083875C168563851 @default.
- W2028083875 hasConceptScore W2028083875C177713679 @default.
- W2028083875 hasConceptScore W2028083875C185592680 @default.
- W2028083875 hasConceptScore W2028083875C203092338 @default.
- W2028083875 hasConceptScore W2028083875C2779343474 @default.
- W2028083875 hasConceptScore W2028083875C2781197716 @default.
- W2028083875 hasConceptScore W2028083875C535046627 @default.
- W2028083875 hasConceptScore W2028083875C55493867 @default.
- W2028083875 hasConceptScore W2028083875C71924100 @default.
- W2028083875 hasConceptScore W2028083875C86803240 @default.
- W2028083875 hasLocation W20280838751 @default.
- W2028083875 hasLocation W20280838752 @default.
- W2028083875 hasLocation W20280838753 @default.
- W2028083875 hasLocation W20280838754 @default.
- W2028083875 hasOpenAccess W2028083875 @default.
- W2028083875 hasPrimaryLocation W20280838751 @default.
- W2028083875 hasRelatedWork W1645224590 @default.
- W2028083875 hasRelatedWork W1972249949 @default.
- W2028083875 hasRelatedWork W1984684769 @default.
- W2028083875 hasRelatedWork W1984732538 @default.
- W2028083875 hasRelatedWork W1994608393 @default.
- W2028083875 hasRelatedWork W2004651054 @default.
- W2028083875 hasRelatedWork W2013683597 @default.
- W2028083875 hasRelatedWork W2037075687 @default.
- W2028083875 hasRelatedWork W2045521109 @default.
- W2028083875 hasRelatedWork W2054192965 @default.
- W2028083875 hasRelatedWork W2121988265 @default.
- W2028083875 hasRelatedWork W2125938207 @default.
- W2028083875 hasRelatedWork W2131356926 @default.
- W2028083875 hasRelatedWork W2234296225 @default.
- W2028083875 hasRelatedWork W2279460660 @default.
- W2028083875 hasRelatedWork W2340511247 @default.
- W2028083875 hasRelatedWork W2416186763 @default.
- W2028083875 hasRelatedWork W2990592364 @default.
- W2028083875 hasRelatedWork W3153859749 @default.
- W2028083875 isParatext "false" @default.
- W2028083875 isRetracted "false" @default.
- W2028083875 magId "2028083875" @default.
- W2028083875 workType "article" @default.