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• W2028089969 abstract "Expression of the neuronal marker 14-3-2 or NSE (neuron-specific enolase) has been studied during in vitro differentiation of cells in culture. The 14-3-2 protein of neuroblastoma cells is immunologically identical with that found in mouse brain extract. The lack of detectable 14-3-2 in cultures of non-neuronal lines shows that this protein, as has been already shown in vivo, is also a specific marker of neurons in vitro. The presence of 14-3-2 in a differentiated hypothalamic clone—but not in its presumptive precursor—indicates selective initial derepression of 14-3-2. Moreover, modulation of the amount of 14-3-2 already present in dividing neuroblastoma cells is related to the confluent phase of growth or morphological differentiation of neuroblasts. Both mechanisms may be related to the mechanisms underlying initial differentiation and subsequent maturation of neurons in vivo. In dividing neuroblastoma cells modulation of the basal level of 14-3-2 is not necessarily associated with expression of the morphological differentiation, but seems generally concomitant with an arrest of cell division." @default.
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• W2028089969 date "1980-01-01" @default.
• W2028089969 modified "2023-10-18" @default.
• W2028089969 title "Expression of a specific neuronal protein, 14-3-2, during in vitro differentiation of neuroblastoma cells" @default.
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• W2028089969 doi "https://doi.org/10.1016/0014-4827(80)90207-4" @default.
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