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- W2028091931 abstract "Investigating the metabolic functions of the nuclear receptor peroxisome proliferator-activated receptor<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E2><mml:mi>γ</mml:mi></mml:math>(PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E3><mml:mi>γ</mml:mi></mml:math>) has been extremely rewarding over the past years. Uncovering the biologic roles of PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E4><mml:mi>γ</mml:mi></mml:math>and its mechanism of action has greatly advanced our understanding of the transcriptional control of lipid and glucose metabolism, and compounds such as thiazolidinediones which directly regulate PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E5><mml:mi>γ</mml:mi></mml:math>have proven to exhibit potent insulin-sensitizer effects in the treatment of diabetes. We review here recent advances on the emerging role of growth hormone releasing peptides in regulating PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E6><mml:mi>γ</mml:mi></mml:math>through interaction with scavenger receptor CD36 and ghrelin GHS-R1a receptor. With the impact that these peptides exert on the metabolic pathways involved in lipid metabolism and energy homeostasis, it is hoped that the development of novel approaches in the regulation of PPAR functions will bring additional therapeutic possibilities to face problems related to metabolic diseases." @default.
- W2028091931 created "2016-06-24" @default.
- W2028091931 creator A5037022694 @default.
- W2028091931 creator A5046862139 @default.
- W2028091931 creator A5090257416 @default.
- W2028091931 date "2008-01-01" @default.
- W2028091931 modified "2023-10-18" @default.
- W2028091931 title "Hexarelin Signaling to PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E1><mml:mi>γ</mml:mi></mml:math>in Metabolic Diseases" @default.
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- W2028091931 doi "https://doi.org/10.1155/2008/364784" @default.
- W2028091931 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2233980" @default.
- W2028091931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18288286" @default.