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• W2028093259 abstract "Studies of circular permutants have demonstrated that the folding reaction of S6 from Thermus thermophilus (S6T) is malleable and responds in an ordered manner to changes of the sequence separation between interacting residues: the S6T permutants retain a common nucleation pattern in the form of a two-strand-helix motif that can be recruited from different parts of the structure. To further test the robustness of the two-strand-helix nucleus we have here determined the crystal structure and folding reaction of an evolutionary divergent S6 protein from the hyperthermophilic bacterium Aquifex aeolicus (S6A). Although the overall topology of S6A is very similar to that of S6T the architecture of the hydrophobic core is radically different by containing a large proportion of stacked Phe side-chains. Despite this disparate core composition, the folding rate constant and the kinetic m values of S6A are identical to those of S6T. The folding nucleus of S6A is also found to retain the characteristic two-strand-helix motif of the S6T permutants, but with a new structural emphasis. The results suggest that the protein folding reaction is linked to topology only in the sense that the native-state topology determines the repertoire of accessible nucleation motifs. If the native structure allows several equivalent ways of recruiting a productive nucleus the folding reaction is free to redistribute within these topological constraints." @default.
• W2028093259 created "2016-06-24" @default.
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• W2028093259 date "2007-01-01" @default.
• W2028093259 modified "2023-09-29" @default.
• W2028093259 title "Folding of S6 Structures with Divergent Amino Acid Composition: Pathway Flexibility Within Partly Overlapping Foldons" @default.
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• W2028093259 doi "https://doi.org/10.1016/j.jmb.2006.09.016" @default.
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