FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028093321> ?p ?o ?g. }

• W2028093321 endingPage "1732" @default.
• W2028093321 startingPage "1724" @default.
• W2028093321 abstract "Leukemia inhibitory factor (LIF) is a pleiotropic cytokine that is essential for blastocyst implantation in mice. It has been suggested that LIF may play a role in human first trimester extravillous trophoblast (EVT) invasion. The aim of the present study was to establish whether LIF induces changes in EVT function related to invasiveness.Primary first trimester human EVT cell cultures were treated with/without LIF and the effects on cell adhesion to fibronectin (FN), vitronectin (VN) and laminin (LN) were assessed. Transcript levels of integrin subunits that mediate cell adhesion to these extracellular matrix (ECM) elements were determined by real-time RT-PCR. Matrix metalloproteinase (MMP)2 and MMP9 secretion was assessed by gelatine zymography and tissue inhibitors matrix metalloproteinase (TIMP) -1 and TIMP-2 secretion by enzyme-linked immunosorbent assay.EVT cells showed increased adhesion to FN, VN and LN ECM elements in response to LIF (20, 20 and 29%, respectively, P < 0.05 FN and VN compared to control; and P < 0.001 LN compared to control). Integrin beta(4) mRNA levels decreased by 50% following LIF treatment (P < 0.001 versus control). MMP2 and MMP9 secretion was not affected by LIF but LIF did increase secretion of TIMP-1 and -2 (P < 0.001 versus control). LIF stimulated the phosphorylation of signal transducer and activator of transcription (STAT) 3 protein while it did not affect STAT3 protein abundance. The addition of a LIF inhibitor attenuated the LIF-induced STAT3 phosphorylation in EVT.The results suggest that LIF can regulate EVT invasion, suggesting an important role in early placental development." @default.
• W2028093321 created "2016-06-24" @default.
• W2028093321 creator A5045663610 @default.
• W2028093321 creator A5047753337 @default.
• W2028093321 creator A5085975673 @default.
• W2028093321 creator A5086000808 @default.
• W2028093321 date "2008-05-15" @default.
• W2028093321 modified "2023-09-27" @default.
• W2028093321 title "Leukemia inhibitory factor promotes human first trimester extravillous trophoblast adhesion to extracellular matrix and secretion of tissue inhibitor of metalloproteinases-1 and -2" @default.
• W2028093321 cites W1533917965 @default.
• W2028093321 cites W1755709221 @default.
• W2028093321 cites W1779691448 @default.
• W2028093321 cites W1966739459 @default.
• W2028093321 cites W1995559307 @default.
• W2028093321 cites W1998638951 @default.
• W2028093321 cites W2002923891 @default.
• W2028093321 cites W2009856290 @default.
• W2028093321 cites W2017758502 @default.
• W2028093321 cites W2020492890 @default.
• W2028093321 cites W2023447334 @default.
• W2028093321 cites W2026011635 @default.
• W2028093321 cites W2035326978 @default.
• W2028093321 cites W2036180939 @default.
• W2028093321 cites W2037990541 @default.
• W2028093321 cites W2046575845 @default.
• W2028093321 cites W2054928345 @default.
• W2028093321 cites W2066385030 @default.
• W2028093321 cites W2068185553 @default.
• W2028093321 cites W2074343850 @default.
• W2028093321 cites W2074356498 @default.
• W2028093321 cites W2078156035 @default.
• W2028093321 cites W2079136332 @default.
• W2028093321 cites W2080037764 @default.
• W2028093321 cites W2080041227 @default.
• W2028093321 cites W2080671719 @default.
• W2028093321 cites W2088788781 @default.
• W2028093321 cites W2102876507 @default.
• W2028093321 cites W2104867031 @default.
• W2028093321 cites W2106939328 @default.
• W2028093321 cites W2109132351 @default.
• W2028093321 cites W2124429884 @default.
• W2028093321 cites W2130236199 @default.
• W2028093321 cites W2143554821 @default.
• W2028093321 cites W2145782275 @default.
• W2028093321 cites W2145809469 @default.
• W2028093321 cites W2147770859 @default.
• W2028093321 cites W2156293127 @default.
• W2028093321 cites W2159980541 @default.
• W2028093321 cites W2161068085 @default.
• W2028093321 cites W2166877247 @default.
• W2028093321 cites W2291798824 @default.
• W2028093321 cites W4239231588 @default.
• W2028093321 cites W4239430742 @default.
• W2028093321 cites W4239965704 @default.
• W2028093321 cites W4249934457 @default.
• W2028093321 cites W4256214420 @default.
• W2028093321 doi "https://doi.org/10.1093/humrep/den121" @default.
• W2028093321 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2474668" @default.
• W2028093321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18492704" @default.
• W2028093321 hasPublicationYear "2008" @default.
• W2028093321 type Work @default.
• W2028093321 sameAs 2028093321 @default.
• W2028093321 citedByCount "88" @default.
• W2028093321 countsByYear W20280933212012 @default.
• W2028093321 countsByYear W20280933212013 @default.
• W2028093321 countsByYear W20280933212014 @default.
• W2028093321 countsByYear W20280933212015 @default.
• W2028093321 countsByYear W20280933212016 @default.
• W2028093321 countsByYear W20280933212017 @default.
• W2028093321 countsByYear W20280933212018 @default.
• W2028093321 countsByYear W20280933212019 @default.
• W2028093321 countsByYear W20280933212020 @default.
• W2028093321 countsByYear W20280933212021 @default.
• W2028093321 countsByYear W20280933212022 @default.
• W2028093321 countsByYear W20280933212023 @default.
• W2028093321 crossrefType "journal-article" @default.
• W2028093321 hasAuthorship W2028093321A5045663610 @default.
• W2028093321 hasAuthorship W2028093321A5047753337 @default.
• W2028093321 hasAuthorship W2028093321A5085975673 @default.
• W2028093321 hasAuthorship W2028093321A5086000808 @default.
• W2028093321 hasBestOaLocation W20280933211 @default.
• W2028093321 hasConcept C104317684 @default.
• W2028093321 hasConcept C11988809 @default.
• W2028093321 hasConcept C126322002 @default.
• W2028093321 hasConcept C127561419 @default.
• W2028093321 hasConcept C134018914 @default.
• W2028093321 hasConcept C1491633281 @default.
• W2028093321 hasConcept C151166631 @default.
• W2028093321 hasConcept C164144092 @default.
• W2028093321 hasConcept C172680121 @default.
• W2028093321 hasConcept C189165786 @default.
• W2028093321 hasConcept C195687474 @default.
• W2028093321 hasConcept C203014093 @default.
• W2028093321 hasConcept C27284151 @default.
• W2028093321 hasConcept C2775997469 @default.
• W2028093321 hasConcept C2776953305 @default.
• W2028093321 hasConcept C2777495146 @default.
• W2028093321 hasConcept C2778690821 @default.

• next