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- W2028102857 abstract "The immunostimulatory oligodeoxynucleotide (ODN) BL07 (5′-GCGTCGGTTTCGGTGCTCAC-3′) was identified from the genomic DNA of the probiotic strain Bifidobacterium longum BB536. ODN BL07 stimulated B-lymphocyte proliferation and induced interleukin-12 (IL-12) production in macrophage-like J774.1 cells. ODNs BL07 and BL07S (modified with phosphorothioate backbone) significantly inhibited immunoglobulin E (IgE) production and stimulated interferon-γ (IFN-γ) and IL-12 production, but did not affect IL-4 secretion in murine splenic cells of ovalbumin-primed BALB/c mice. These ODNs also significantly inhibited production of IgE in purified murine B cells in the presence of IL-4 and anti-CD40. The results suggest the potential of ODNs BL07 and BL07S in preventing IgE-related immune responses and the possible involvement of ODN BL07 in the antiallergic efficacy of B. longum BB536." @default.
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- W2028102857 date "2006-04-01" @default.
- W2028102857 modified "2023-10-16" @default.
- W2028102857 title "An immunostimulatory DNA sequence from a probiotic strain of<i>Bifidobacterium longum</i>inhibits IgE production<i>in vitro</i>" @default.
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- W2028102857 doi "https://doi.org/10.1111/j.1574-695x.2006.00064.x" @default.
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