Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028103478> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2028103478 abstract "Epstein-Barr virus (EBV)-associated T/NK-cell lymphoproliferative disorders (LPD) of children and young adults are sometimes termed as severe chronic active EBV infection (CAEBV), and are associated with an aggressive clinical course. However, these clinicopathological states and the role of EBV have not been clarified. A retrospective study was performed on 43 children and adult patients, who manifested EBV-associated T/NK-cell lymphoproliferative disorders (EBV-T/NK-LPD) and most of whom had experienced general illness with CAEBV for several months or years. Clinicopathologically, 43 patients were classified into four groups: group A (smoldering state) (n=7), morphological non-neoplastic LPD with chronic clinical course (several years); group B (chronic state) (n=10), non-neoplastic LPD with clonal EBV-infected cells and a chronic course; group C (leukemia/lymphoma state) (n=22), neoplastic LPD with a subacute course (years to months); group D (fulminant state) (n=4), neoplastic LPD with a fulminant course (weeks to days). The 43 patients comprised 21 males and 22 females. The median age of group A was 14 years, group B 12 years, group C 17 years, and group D 1 year. Four of 7 patients in group A, 3 of 10 in group B, 12 of 22 in group C, and all 4 in group D have died. Causes of death included hemophagocytic syndrome and/or tumor death. Genotypically and phenotypically, group C was composed of peripheral T-cell lymphoma (PTCL), and NK-cell leukemia/lymphoma (NKLL), and group D comprised cases of PTCL. Groups A and B exhibited increased NK- or T-cells (CD8>CD4), and rare B-cells. Serologic titers of EBV were only modestly elevated or not elevated in almost all cases. EBV early RNA-1 (EBER-1)-expressing EBV-infected cells were frequently encountered in each group, but the number of infected cells varied between the cases. The EBV genotype did not differ between the groups. Our findings support an important pathogenic role for EBV-infected T/NK-cell infection, rather than the EBV state, in CAEBV and consequent EBV-associated NK/T-neoplasia." @default.
- W2028103478 created "2016-06-24" @default.
- W2028103478 creator A5001399725 @default.
- W2028103478 creator A5018322323 @default.
- W2028103478 creator A5046162726 @default.
- W2028103478 creator A5046638834 @default.
- W2028103478 creator A5049351305 @default.
- W2028103478 creator A5058015772 @default.
- W2028103478 creator A5070398449 @default.
- W2028103478 creator A5080232316 @default.
- W2028103478 date "2004-05-01" @default.
- W2028103478 modified "2023-09-25" @default.
- W2028103478 title "Clinicopathological states of Epstein-Barr virus-associated T/NK-cell lymphoproliferative disorders (severe chronic active EBV infection) of children and young adults" @default.
- W2028103478 doi "https://doi.org/10.3892/ijo.24.5.1165" @default.
- W2028103478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15067338" @default.
- W2028103478 hasPublicationYear "2004" @default.
- W2028103478 type Work @default.
- W2028103478 sameAs 2028103478 @default.
- W2028103478 citedByCount "21" @default.
- W2028103478 countsByYear W20281034782013 @default.
- W2028103478 countsByYear W20281034782014 @default.
- W2028103478 countsByYear W20281034782015 @default.
- W2028103478 countsByYear W20281034782018 @default.
- W2028103478 countsByYear W20281034782019 @default.
- W2028103478 countsByYear W20281034782022 @default.
- W2028103478 crossrefType "journal-article" @default.
- W2028103478 hasAuthorship W2028103478A5001399725 @default.
- W2028103478 hasAuthorship W2028103478A5018322323 @default.
- W2028103478 hasAuthorship W2028103478A5046162726 @default.
- W2028103478 hasAuthorship W2028103478A5046638834 @default.
- W2028103478 hasAuthorship W2028103478A5049351305 @default.
- W2028103478 hasAuthorship W2028103478A5058015772 @default.
- W2028103478 hasAuthorship W2028103478A5070398449 @default.
- W2028103478 hasAuthorship W2028103478A5080232316 @default.
- W2028103478 hasConcept C126322002 @default.
- W2028103478 hasConcept C203014093 @default.
- W2028103478 hasConcept C2522874641 @default.
- W2028103478 hasConcept C2776995267 @default.
- W2028103478 hasConcept C2779338263 @default.
- W2028103478 hasConcept C2781107259 @default.
- W2028103478 hasConcept C2781375147 @default.
- W2028103478 hasConcept C71924100 @default.
- W2028103478 hasConcept C90924648 @default.
- W2028103478 hasConceptScore W2028103478C126322002 @default.
- W2028103478 hasConceptScore W2028103478C203014093 @default.
- W2028103478 hasConceptScore W2028103478C2522874641 @default.
- W2028103478 hasConceptScore W2028103478C2776995267 @default.
- W2028103478 hasConceptScore W2028103478C2779338263 @default.
- W2028103478 hasConceptScore W2028103478C2781107259 @default.
- W2028103478 hasConceptScore W2028103478C2781375147 @default.
- W2028103478 hasConceptScore W2028103478C71924100 @default.
- W2028103478 hasConceptScore W2028103478C90924648 @default.
- W2028103478 hasLocation W20281034781 @default.
- W2028103478 hasLocation W20281034782 @default.
- W2028103478 hasOpenAccess W2028103478 @default.
- W2028103478 hasPrimaryLocation W20281034781 @default.
- W2028103478 hasRelatedWork W141443462 @default.
- W2028103478 hasRelatedWork W15108618 @default.
- W2028103478 hasRelatedWork W1605230984 @default.
- W2028103478 hasRelatedWork W1972115977 @default.
- W2028103478 hasRelatedWork W2026304756 @default.
- W2028103478 hasRelatedWork W2031423829 @default.
- W2028103478 hasRelatedWork W2038035645 @default.
- W2028103478 hasRelatedWork W2052425622 @default.
- W2028103478 hasRelatedWork W2058915720 @default.
- W2028103478 hasRelatedWork W2073631928 @default.
- W2028103478 hasRelatedWork W2094342081 @default.
- W2028103478 hasRelatedWork W2104223678 @default.
- W2028103478 hasRelatedWork W2124868174 @default.
- W2028103478 hasRelatedWork W2154227505 @default.
- W2028103478 hasRelatedWork W2159517806 @default.
- W2028103478 hasRelatedWork W2159580351 @default.
- W2028103478 hasRelatedWork W2162251899 @default.
- W2028103478 hasRelatedWork W2166844298 @default.
- W2028103478 hasRelatedWork W2327153404 @default.
- W2028103478 hasRelatedWork W2412326054 @default.
- W2028103478 isParatext "false" @default.
- W2028103478 isRetracted "false" @default.
- W2028103478 magId "2028103478" @default.
- W2028103478 workType "article" @default.