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- W2028107325 abstract "Five 1-oximino-1-nitro compounds (nitrolic acids) were prepared and tested for antithrombotic and blood pressure lowering activities. 1-Nitro-ethanone 1-oxime (1, ethylnitrolic acid) 2 h after oral administration to rats inhibited thrombus formation by a laser beam in mesenteric arterioles of rats by 69% and by 46% in venules (60 mg/kg). The blood pressure of SHR rats even at this high dose only was decreased by 10% suggesting that antithrombotic and blood pressure effects can be dissociated. The in vitro decomposition of 1 at 37 degrees C nearly exclusively gave N2O and acetic acid indicating that HNO primarily had been formed." @default.
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- W2028107325 date "1996-01-01" @default.
- W2028107325 modified "2023-10-14" @default.
- W2028107325 title "New NO-Donors with Antithrombotic and Vasodilating Activities, Part 15 Nitrolic Acids" @default.
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- W2028107325 doi "https://doi.org/10.1002/ardp.19963290205" @default.
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