Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028109121> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2028109121 endingPage "168" @default.
- W2028109121 startingPage "159" @default.
- W2028109121 abstract "Unopposed oestrogen replacement therapy increases the risk of endometrial cancer in post-menopausal women. However, the addition of progestogen to the oestrogen therapy reduces the risk of endometrial carcinoma by preventing and effectively treating hyperplasia of the endometrium. In a 5-yr prospective study with a further 4 yr of follow-up (1975–1983), 31 adenocarcinomas of the endometrium were detected over 27243 patient-years of observation, for an incidence of 113.8:100000 women. The first report on the results of the study appeared in 1978; this paper presents further results. The lowest incidence of endometrial cancer (49.0:100000) was observed among the oestrogen-progestogen users and the highest (390.6:100000) among the unopposed oestrogen users. Not only was the incidence of endometrial carcinoma significantly lower in the oestrogen-progestogen users than in those using unopposed oestrogens (P ⩽ 0.0001), but it was also significantly lower than that among the non-hormone users (245.5:100000 with P ⩽ 0.005). Endometrial hyperplasia had been diagnosed previously in 12 of the 31 patients with adenocarcinoma (38.7%) from 4 mth to 8 yr before the detection of cancer. When given for 7–10 days each month progestogens are effective in reversing hyperplasia and restoring a normal endometrium in 94.5% of patients treated within 3–6 mth. The progestogen challenge test was devised to identify post-menopausal women at greatest risk for adenocarcinoma of the endometrium. It is concluded that the use of this test will reduce the risk of endometrial cancer in both oestrogen-treated post-menopausal women and women with increased endogenous oestrogens." @default.
- W2028109121 created "2016-06-24" @default.
- W2028109121 creator A5060466120 @default.
- W2028109121 date "1986-07-01" @default.
- W2028109121 modified "2023-09-27" @default.
- W2028109121 title "Prevention of endometrial cancer with progestogens" @default.
- W2028109121 cites W1971581458 @default.
- W2028109121 cites W2006398865 @default.
- W2028109121 cites W2016766895 @default.
- W2028109121 cites W2079736780 @default.
- W2028109121 cites W2159249210 @default.
- W2028109121 cites W2222541464 @default.
- W2028109121 cites W2314282709 @default.
- W2028109121 cites W2314604683 @default.
- W2028109121 cites W2335854637 @default.
- W2028109121 cites W2340750934 @default.
- W2028109121 cites W2399189465 @default.
- W2028109121 cites W4234257588 @default.
- W2028109121 doi "https://doi.org/10.1016/0378-5122(86)90022-8" @default.
- W2028109121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3747849" @default.
- W2028109121 hasPublicationYear "1986" @default.
- W2028109121 type Work @default.
- W2028109121 sameAs 2028109121 @default.
- W2028109121 citedByCount "120" @default.
- W2028109121 countsByYear W20281091212012 @default.
- W2028109121 countsByYear W20281091212014 @default.
- W2028109121 countsByYear W20281091212016 @default.
- W2028109121 countsByYear W20281091212017 @default.
- W2028109121 crossrefType "journal-article" @default.
- W2028109121 hasAuthorship W2028109121A5060466120 @default.
- W2028109121 hasConcept C120665830 @default.
- W2028109121 hasConcept C121332964 @default.
- W2028109121 hasConcept C121608353 @default.
- W2028109121 hasConcept C126322002 @default.
- W2028109121 hasConcept C131872663 @default.
- W2028109121 hasConcept C143998085 @default.
- W2028109121 hasConcept C188816634 @default.
- W2028109121 hasConcept C2775904963 @default.
- W2028109121 hasConcept C2777088508 @default.
- W2028109121 hasConcept C2777164284 @default.
- W2028109121 hasConcept C2777546739 @default.
- W2028109121 hasConcept C2777689261 @default.
- W2028109121 hasConcept C2779742232 @default.
- W2028109121 hasConcept C2780572241 @default.
- W2028109121 hasConcept C29456083 @default.
- W2028109121 hasConcept C61511704 @default.
- W2028109121 hasConcept C71924100 @default.
- W2028109121 hasConceptScore W2028109121C120665830 @default.
- W2028109121 hasConceptScore W2028109121C121332964 @default.
- W2028109121 hasConceptScore W2028109121C121608353 @default.
- W2028109121 hasConceptScore W2028109121C126322002 @default.
- W2028109121 hasConceptScore W2028109121C131872663 @default.
- W2028109121 hasConceptScore W2028109121C143998085 @default.
- W2028109121 hasConceptScore W2028109121C188816634 @default.
- W2028109121 hasConceptScore W2028109121C2775904963 @default.
- W2028109121 hasConceptScore W2028109121C2777088508 @default.
- W2028109121 hasConceptScore W2028109121C2777164284 @default.
- W2028109121 hasConceptScore W2028109121C2777546739 @default.
- W2028109121 hasConceptScore W2028109121C2777689261 @default.
- W2028109121 hasConceptScore W2028109121C2779742232 @default.
- W2028109121 hasConceptScore W2028109121C2780572241 @default.
- W2028109121 hasConceptScore W2028109121C29456083 @default.
- W2028109121 hasConceptScore W2028109121C61511704 @default.
- W2028109121 hasConceptScore W2028109121C71924100 @default.
- W2028109121 hasIssue "2" @default.
- W2028109121 hasLocation W20281091211 @default.
- W2028109121 hasLocation W20281091212 @default.
- W2028109121 hasOpenAccess W2028109121 @default.
- W2028109121 hasPrimaryLocation W20281091211 @default.
- W2028109121 hasRelatedWork W2003312069 @default.
- W2028109121 hasRelatedWork W2028109121 @default.
- W2028109121 hasRelatedWork W2065220856 @default.
- W2028109121 hasRelatedWork W2078253894 @default.
- W2028109121 hasRelatedWork W2129680759 @default.
- W2028109121 hasRelatedWork W2401668395 @default.
- W2028109121 hasRelatedWork W2409726297 @default.
- W2028109121 hasRelatedWork W2987949937 @default.
- W2028109121 hasRelatedWork W3034389813 @default.
- W2028109121 hasRelatedWork W2301330970 @default.
- W2028109121 hasVolume "8" @default.
- W2028109121 isParatext "false" @default.
- W2028109121 isRetracted "false" @default.
- W2028109121 magId "2028109121" @default.
- W2028109121 workType "article" @default.