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- W2028114037 abstract "N-nitrosoamides of 7β-hydroxylated bile acid conjugates, particularly of the ursodeoxycholic acid family have been synthesized. The products and synthetic intermediates were fully characterized by the results of high-resolution 1H NMR, FT-IR, FABMS and ESI-MS studies. The compounds, N-nitrosoglycoursodeoxycholic acid (NOGUDCA), N-nitrosoglycoursocholic acid (NOGUCA) and N-nitrosoglycodeoxycholic acid (NOGDCA) decomposed between pH 6 and 9 in aqueous buffer solutions, indicating a t12 of 5–7 h while N-nitrosotauroursodeoxycholic acid (NOTUDCA) indicated a much longer t12 of 15–17 h. These results suggest that the compounds are relatively stable and may enter the enterohepatic circulation. Their decomposition is similar to that of other N-nitrosamides, which generate alkylating agents and thereby act as DNA mutagens." @default.
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- W2028114037 date "1996-06-01" @default.
- W2028114037 modified "2023-09-27" @default.
- W2028114037 title "Chemical synthesis, structural analysis, and decomposition of N-nitroso bile acid conjugates" @default.
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- W2028114037 doi "https://doi.org/10.1016/0968-0896(96)00084-3" @default.
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