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- W2028118572 abstract "The course of vincristine-induced neuropathy was evaluated in 14 patients who developed muscle cramps during chemotherapy. Cramps were noticed between 3 days and 4 months after the initiation of vincristine and following a cumulative dose of 1-9.4 mg/m2 (median 3.1 mg/m2). All patients reported daytime cramps and only 4 experienced nocturnal cramps. The lower extremities were involved in 11/14 and the upper extremities in 10/14 patients. Duration of cramps ranged from 1 to > 9 months. Physical examination revealed signs of peripheral neuropathy in all patients. Cramps were the first symptom of neurotoxicity in 4 patients. Other symptoms were noted in all patients, but only 3 had motor manifestations other than muscle cramps. Although symptoms of neuropathy tended to persist for several months, a rapid symptomatic improvement was noticed after withdrawal of vincristine. We conclude that vincristine-induced muscle cramps are not necessarily associated with severe neurotoxicity and should not automatically indicate interruption of therapy." @default.
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- W2028118572 date "1991-01-01" @default.
- W2028118572 modified "2023-09-25" @default.
- W2028118572 title "Muscle Cramps Associated with Vincristine Therapy" @default.
- W2028118572 cites W1975031667 @default.
- W2028118572 doi "https://doi.org/10.3109/02841869109092444" @default.
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