FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028130173> ?p ?o ?g. }

• W2028130173 endingPage "186" @default.
• W2028130173 startingPage "182" @default.
• W2028130173 abstract "The cause of asthma, which has been linked to a chronic, T-cell-mediated bronchial inflammation, remains unclear. A number of other T-lymphocyte-mediated, chronic inflammatory disorders have been associated with autoimmunity and there are data indicating that autoimmune phenomena might also be present in asthma. Expression of perforin, a cytotoxic molecule produced by lymphocytes, has been implicated in the pathogenesis of autoimmune diseases. We therefore tested the hypothesis that allergic and intrinsic asthma might be associated with an increase in lymphocytes producing perforin by comparing the expression of intracellular perforin in peripheral blood lymphocytes of patients with extrinsic asthma (n = 13), intrinsic asthma (n = 7), and healthy control subjects (n = 18). Lymphocytes were identified using flow cytometry and subdivided into CD3(+), CD4(+), CD8(+), CD16(+), and CD56(+) subpopulations after staining with appropriate monoclonal antibodies. The percentage of perforin-positive total lymphocytes was significantly elevated in patients with allergic as well as intrinsic asthma when compared with normal control subjects. Analysis of lymphocyte subpopulations also revealed a significant increase in the percentage of CD3(+), CD4(+), CD8(+), and CD56(+) cells expressing perforin in allergic asthma and a significant increase in the percentage of CD4(+) and CD56(+) cells in intrinsic asthma when compared with healthy control subjects. Perforin expression in CD4(+) cells in intrinsic asthma was also significantly elevated compared with allergic asthma. We conclude that allergic and intrinsic asthma is associated with increased expression of perforin in T-lymphocyte subsets." @default.
• W2028130173 created "2016-06-24" @default.
• W2028130173 creator A5014502643 @default.
• W2028130173 creator A5018466627 @default.
• W2028130173 creator A5018617210 @default.
• W2028130173 creator A5020646722 @default.
• W2028130173 creator A5058720249 @default.
• W2028130173 creator A5088108108 @default.
• W2028130173 date "2000-01-01" @default.
• W2028130173 modified "2023-10-05" @default.
• W2028130173 title "Increase in Perforin-positive Peripheral Blood Lymphocytes in Extrinsic and Intrinsic Asthma" @default.
• W2028130173 cites W1964846342 @default.
• W2028130173 cites W1977299595 @default.
• W2028130173 cites W1983424507 @default.
• W2028130173 cites W1984150698 @default.
• W2028130173 cites W1996616758 @default.
• W2028130173 cites W2004907804 @default.
• W2028130173 cites W2010692342 @default.
• W2028130173 cites W2015813372 @default.
• W2028130173 cites W2022247288 @default.
• W2028130173 cites W2026878918 @default.
• W2028130173 cites W2031303172 @default.
• W2028130173 cites W2035626424 @default.
• W2028130173 cites W2035942694 @default.
• W2028130173 cites W2055540297 @default.
• W2028130173 cites W2056086692 @default.
• W2028130173 cites W2057239472 @default.
• W2028130173 cites W2063420993 @default.
• W2028130173 cites W2085188839 @default.
• W2028130173 cites W2085330430 @default.
• W2028130173 cites W2085670792 @default.
• W2028130173 cites W2088379862 @default.
• W2028130173 cites W2163105800 @default.
• W2028130173 cites W2170801997 @default.
• W2028130173 cites W2188113314 @default.
• W2028130173 cites W2286672994 @default.
• W2028130173 cites W2312870247 @default.
• W2028130173 doi "https://doi.org/10.1164/ajrccm.161.1.9902104" @default.
• W2028130173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10619818" @default.
• W2028130173 hasPublicationYear "2000" @default.
• W2028130173 type Work @default.
• W2028130173 sameAs 2028130173 @default.
• W2028130173 citedByCount "31" @default.
• W2028130173 countsByYear W20281301732012 @default.
• W2028130173 countsByYear W20281301732013 @default.
• W2028130173 countsByYear W20281301732014 @default.
• W2028130173 countsByYear W20281301732015 @default.
• W2028130173 countsByYear W20281301732017 @default.
• W2028130173 countsByYear W20281301732018 @default.
• W2028130173 countsByYear W20281301732023 @default.
• W2028130173 crossrefType "journal-article" @default.
• W2028130173 hasAuthorship W2028130173A5014502643 @default.
• W2028130173 hasAuthorship W2028130173A5018466627 @default.
• W2028130173 hasAuthorship W2028130173A5018617210 @default.
• W2028130173 hasAuthorship W2028130173A5020646722 @default.
• W2028130173 hasAuthorship W2028130173A5058720249 @default.
• W2028130173 hasAuthorship W2028130173A5088108108 @default.
• W2028130173 hasConcept C114684123 @default.
• W2028130173 hasConcept C167672396 @default.
• W2028130173 hasConcept C203014093 @default.
• W2028130173 hasConcept C207480886 @default.
• W2028130173 hasConcept C2776042228 @default.
• W2028130173 hasConcept C2776062744 @default.
• W2028130173 hasConcept C2777761686 @default.
• W2028130173 hasConcept C2780130043 @default.
• W2028130173 hasConcept C2780942790 @default.
• W2028130173 hasConcept C71924100 @default.
• W2028130173 hasConcept C8891405 @default.
• W2028130173 hasConceptScore W2028130173C114684123 @default.
• W2028130173 hasConceptScore W2028130173C167672396 @default.
• W2028130173 hasConceptScore W2028130173C203014093 @default.
• W2028130173 hasConceptScore W2028130173C207480886 @default.
• W2028130173 hasConceptScore W2028130173C2776042228 @default.
• W2028130173 hasConceptScore W2028130173C2776062744 @default.
• W2028130173 hasConceptScore W2028130173C2777761686 @default.
• W2028130173 hasConceptScore W2028130173C2780130043 @default.
• W2028130173 hasConceptScore W2028130173C2780942790 @default.
• W2028130173 hasConceptScore W2028130173C71924100 @default.
• W2028130173 hasConceptScore W2028130173C8891405 @default.
• W2028130173 hasIssue "1" @default.
• W2028130173 hasLocation W20281301731 @default.
• W2028130173 hasLocation W20281301732 @default.
• W2028130173 hasOpenAccess W2028130173 @default.
• W2028130173 hasPrimaryLocation W20281301731 @default.
• W2028130173 hasRelatedWork W1988960013 @default.
• W2028130173 hasRelatedWork W2007493927 @default.
• W2028130173 hasRelatedWork W2056385328 @default.
• W2028130173 hasRelatedWork W2096287500 @default.
• W2028130173 hasRelatedWork W2182570330 @default.
• W2028130173 hasRelatedWork W2186316345 @default.
• W2028130173 hasRelatedWork W2375180626 @default.
• W2028130173 hasRelatedWork W2385418199 @default.
• W2028130173 hasRelatedWork W3029329823 @default.
• W2028130173 hasRelatedWork W4210976760 @default.
• W2028130173 hasVolume "161" @default.
• W2028130173 isParatext "false" @default.
• W2028130173 isRetracted "false" @default.
• W2028130173 magId "2028130173" @default.

• next