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- W2028132904 abstract "Micro-RNA-145 (miR145), a tumor suppressor miR, dramatically inhibits growth of cancer cells in culture and plays a significant role in human stem cells differentiation. We have isolated a human genomic sequence of 864 bp comprising the pre-miR and its flanking sequences. The cloned miR145 genomic sequence expresses a mature miR145 in transfected cells. We show here that flanking sequences on either side of the pre-miR sequence can modulate its expression levels. Surprisingly, a highly conserved sequence 3′ to the pre-miR plays a crucial role in miR145 expression. J. Cell. Physiol. 226: 602–607, 2011. © 2010 Wiley-Liss, Inc." @default.
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- W2028132904 date "2010-12-28" @default.
- W2028132904 modified "2023-10-16" @default.
- W2028132904 title "Expression of Micro-RNA-145 is regulated by a highly conserved genomic sequence 3′ to the pre-miR" @default.
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- W2028132904 doi "https://doi.org/10.1002/jcp.22368" @default.
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