Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028133055> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2028133055 endingPage "172" @default.
- W2028133055 startingPage "159" @default.
- W2028133055 abstract "Summary. Factor X is one of the vitamin-K-dependent serine proteases. As a result of its position at the convergence of the intrinsic and extrinsic pathways of the clotting cascade, it plays a crucial role in blood coagulation. Factor X interacts with components of both pathways of coagulation, leading to its activation and the formation of the prothrombinase complex. The gene for factor X has been cloned and sequenced and maps to the long arm of chromosome 13, approximately 2.8 kb downstream of the factor VII gene. Each of the exons of factor X encodes a specific functional domain within the protein. In terms of its gene structure and amino acid sequence, factor X shows significant homology with other vitamin-K-dependent clotting factors, suggesting an origin in some common ancestral protein. Factor X deficiency is one of the rarest of the inherited coagulation disorders. Such deficiencies are inherited in an autosomal recessive manner and are characterized by a variable bleeding tendency. In its homozygous form, factor X deficiency has an estimated prevalence of 1:500 000 but in its heterozygous form it has an estimated frequency of ∼1:500 although affected individuals are often clinically asymptomatic. Acquired deficiencies of factor X are uncommon and in isolation are seen most frequently in patients with amyloidosis and in association with upper respiratory tract infections. Treatment of the deficiency state involves factor X replacement with either fresh frozen plasma or prothrombin complex concentrates. However, the latter may be associated with an increased risk of thrombosis." @default.
- W2028133055 created "2016-06-24" @default.
- W2028133055 creator A5027609483 @default.
- W2028133055 date "1997-07-01" @default.
- W2028133055 modified "2023-09-30" @default.
- W2028133055 title "Factor X and its deficiency states" @default.
- W2028133055 doi "https://doi.org/10.1046/j.1365-2516.1997.00106.x" @default.
- W2028133055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27214799" @default.
- W2028133055 hasPublicationYear "1997" @default.
- W2028133055 type Work @default.
- W2028133055 sameAs 2028133055 @default.
- W2028133055 citedByCount "38" @default.
- W2028133055 countsByYear W20281330552012 @default.
- W2028133055 countsByYear W20281330552015 @default.
- W2028133055 countsByYear W20281330552016 @default.
- W2028133055 countsByYear W20281330552018 @default.
- W2028133055 countsByYear W20281330552019 @default.
- W2028133055 countsByYear W20281330552021 @default.
- W2028133055 countsByYear W20281330552022 @default.
- W2028133055 countsByYear W20281330552023 @default.
- W2028133055 crossrefType "journal-article" @default.
- W2028133055 hasAuthorship W2028133055A5027609483 @default.
- W2028133055 hasConcept C104317684 @default.
- W2028133055 hasConcept C112516734 @default.
- W2028133055 hasConcept C126322002 @default.
- W2028133055 hasConcept C2776046644 @default.
- W2028133055 hasConcept C2777292125 @default.
- W2028133055 hasConcept C2777444498 @default.
- W2028133055 hasConcept C2778382381 @default.
- W2028133055 hasConcept C2780868729 @default.
- W2028133055 hasConcept C2780930249 @default.
- W2028133055 hasConcept C2781221834 @default.
- W2028133055 hasConcept C2992139802 @default.
- W2028133055 hasConcept C54355233 @default.
- W2028133055 hasConcept C71924100 @default.
- W2028133055 hasConcept C86803240 @default.
- W2028133055 hasConcept C89560881 @default.
- W2028133055 hasConceptScore W2028133055C104317684 @default.
- W2028133055 hasConceptScore W2028133055C112516734 @default.
- W2028133055 hasConceptScore W2028133055C126322002 @default.
- W2028133055 hasConceptScore W2028133055C2776046644 @default.
- W2028133055 hasConceptScore W2028133055C2777292125 @default.
- W2028133055 hasConceptScore W2028133055C2777444498 @default.
- W2028133055 hasConceptScore W2028133055C2778382381 @default.
- W2028133055 hasConceptScore W2028133055C2780868729 @default.
- W2028133055 hasConceptScore W2028133055C2780930249 @default.
- W2028133055 hasConceptScore W2028133055C2781221834 @default.
- W2028133055 hasConceptScore W2028133055C2992139802 @default.
- W2028133055 hasConceptScore W2028133055C54355233 @default.
- W2028133055 hasConceptScore W2028133055C71924100 @default.
- W2028133055 hasConceptScore W2028133055C86803240 @default.
- W2028133055 hasConceptScore W2028133055C89560881 @default.
- W2028133055 hasIssue "3" @default.
- W2028133055 hasLocation W20281330551 @default.
- W2028133055 hasLocation W20281330552 @default.
- W2028133055 hasOpenAccess W2028133055 @default.
- W2028133055 hasPrimaryLocation W20281330551 @default.
- W2028133055 hasRelatedWork W1966887517 @default.
- W2028133055 hasRelatedWork W1970851316 @default.
- W2028133055 hasRelatedWork W1972853286 @default.
- W2028133055 hasRelatedWork W2029576247 @default.
- W2028133055 hasRelatedWork W2037666476 @default.
- W2028133055 hasRelatedWork W2063199350 @default.
- W2028133055 hasRelatedWork W2347867142 @default.
- W2028133055 hasRelatedWork W2398057059 @default.
- W2028133055 hasRelatedWork W2413248771 @default.
- W2028133055 hasRelatedWork W2473782998 @default.
- W2028133055 hasVolume "3" @default.
- W2028133055 isParatext "false" @default.
- W2028133055 isRetracted "false" @default.
- W2028133055 magId "2028133055" @default.
- W2028133055 workType "article" @default.