FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028135093> ?p ?o ?g. }

• W2028135093 endingPage "248" @default.
• W2028135093 startingPage "236" @default.
• W2028135093 abstract "The distribution of cerebellar [3H]muscimol binding sites was studied autoradiographically in normal C57BL/6J mice and in the weaver, reeler, Purkinje cell degeneration and staggerer mutant mice. In the normal 79-day-old mouse cerebellum, the highest concentration of [3H]muscimol binding sites was observed in the granule cell layer. A much lower grain density was present over the Purkinje cell and molecular layers and negligible numbers of binding sites were seen over the deep cerebellar nuclei and white matter. A significant decrease in [3H]muscimol labeling was observed over the cerebellar cortex of the 81–86-day-old weaver mutant; this was most pronounced in the vermis where granule cell loss was the greatest. Over the hemispheres, where fewer granule cells degenerate, a higher density of binding sites remained. In the 27–29-day-old reeler cerebellum, where Purkinje cells are malpositioned, no labeling was seen over the deep Purkinje cell masses. In the quasi-normal superficial cortex, labeling density over the surviving granule cell layer was only slightly decreased. In the 54–57-day-old Purkinje cell degeneration mutant, where essentially all Purkinje cells have disappeared by day 45, a 29% decrease in grain density over the granule cell layer was observed, while labeling was still present in the molecular layer. Virtually no [3H]muscimol labeling was detected over any part of the cerebellar cortex of the 25–27-day-old staggerer mutant (which lacks parallel fiber-Purkinje cell synapses), although clusters of surviving granule cells were present in significant numbers in the lateral aspects of the cortex. Our autoradiographic data indicate that GABAA receptors are associated with granule cells in both the molecular and granule cell layers. Furthermore, our results raise the possibility that the maintenance of receptor levels may be dependent upon synaptic contacts between the granule cell and its main postsynaptic target, the Purkinje cell." @default.
• W2028135093 created "2016-06-24" @default.
• W2028135093 creator A5014322402 @default.
• W2028135093 creator A5063230128 @default.
• W2028135093 creator A5069121298 @default.
• W2028135093 date "1988-01-01" @default.
• W2028135093 modified "2023-09-25" @default.
• W2028135093 title "The localization of GABAA receptors in mice with mutations affecting the structure and connectivity of the cerebellum" @default.
• W2028135093 cites W1964156456 @default.
• W2028135093 cites W1964332206 @default.
• W2028135093 cites W1967780277 @default.
• W2028135093 cites W1979947522 @default.
• W2028135093 cites W1985445187 @default.
• W2028135093 cites W1986868547 @default.
• W2028135093 cites W1990831527 @default.
• W2028135093 cites W1997726536 @default.
• W2028135093 cites W1998467222 @default.
• W2028135093 cites W1999982167 @default.
• W2028135093 cites W2006273621 @default.
• W2028135093 cites W2010789711 @default.
• W2028135093 cites W2012580242 @default.
• W2028135093 cites W2013317069 @default.
• W2028135093 cites W2018576093 @default.
• W2028135093 cites W2037057300 @default.
• W2028135093 cites W2038295723 @default.
• W2028135093 cites W2040230882 @default.
• W2028135093 cites W2042736413 @default.
• W2028135093 cites W2046128576 @default.
• W2028135093 cites W2059714868 @default.
• W2028135093 cites W2065119669 @default.
• W2028135093 cites W2071377230 @default.
• W2028135093 cites W2073767964 @default.
• W2028135093 cites W2093825399 @default.
• W2028135093 cites W2141210991 @default.
• W2028135093 cites W2157006899 @default.
• W2028135093 doi "https://doi.org/10.1016/0006-8993(88)91480-1" @default.
• W2028135093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2833984" @default.
• W2028135093 hasPublicationYear "1988" @default.
• W2028135093 type Work @default.
• W2028135093 sameAs 2028135093 @default.
• W2028135093 citedByCount "20" @default.
• W2028135093 countsByYear W20281350932013 @default.
• W2028135093 countsByYear W20281350932017 @default.
• W2028135093 crossrefType "journal-article" @default.
• W2028135093 hasAuthorship W2028135093A5014322402 @default.
• W2028135093 hasAuthorship W2028135093A5063230128 @default.
• W2028135093 hasAuthorship W2028135093A5069121298 @default.
• W2028135093 hasConcept C105702510 @default.
• W2028135093 hasConcept C151730666 @default.
• W2028135093 hasConcept C168258287 @default.
• W2028135093 hasConcept C169760540 @default.
• W2028135093 hasConcept C170493617 @default.
• W2028135093 hasConcept C185592680 @default.
• W2028135093 hasConcept C2775845787 @default.
• W2028135093 hasConcept C2776464000 @default.
• W2028135093 hasConcept C2777734550 @default.
• W2028135093 hasConcept C2778058767 @default.
• W2028135093 hasConcept C2778063154 @default.
• W2028135093 hasConcept C2778472085 @default.
• W2028135093 hasConcept C2778888523 @default.
• W2028135093 hasConcept C2779188335 @default.
• W2028135093 hasConcept C2779652256 @default.
• W2028135093 hasConcept C2780680797 @default.
• W2028135093 hasConcept C2992333117 @default.
• W2028135093 hasConcept C49760210 @default.
• W2028135093 hasConcept C529278444 @default.
• W2028135093 hasConcept C55493867 @default.
• W2028135093 hasConcept C86803240 @default.
• W2028135093 hasConcept C95444343 @default.
• W2028135093 hasConceptScore W2028135093C105702510 @default.
• W2028135093 hasConceptScore W2028135093C151730666 @default.
• W2028135093 hasConceptScore W2028135093C168258287 @default.
• W2028135093 hasConceptScore W2028135093C169760540 @default.
• W2028135093 hasConceptScore W2028135093C170493617 @default.
• W2028135093 hasConceptScore W2028135093C185592680 @default.
• W2028135093 hasConceptScore W2028135093C2775845787 @default.
• W2028135093 hasConceptScore W2028135093C2776464000 @default.
• W2028135093 hasConceptScore W2028135093C2777734550 @default.
• W2028135093 hasConceptScore W2028135093C2778058767 @default.
• W2028135093 hasConceptScore W2028135093C2778063154 @default.
• W2028135093 hasConceptScore W2028135093C2778472085 @default.
• W2028135093 hasConceptScore W2028135093C2778888523 @default.
• W2028135093 hasConceptScore W2028135093C2779188335 @default.
• W2028135093 hasConceptScore W2028135093C2779652256 @default.
• W2028135093 hasConceptScore W2028135093C2780680797 @default.
• W2028135093 hasConceptScore W2028135093C2992333117 @default.
• W2028135093 hasConceptScore W2028135093C49760210 @default.
• W2028135093 hasConceptScore W2028135093C529278444 @default.
• W2028135093 hasConceptScore W2028135093C55493867 @default.
• W2028135093 hasConceptScore W2028135093C86803240 @default.
• W2028135093 hasConceptScore W2028135093C95444343 @default.
• W2028135093 hasIssue "1-2" @default.
• W2028135093 hasLocation W20281350931 @default.
• W2028135093 hasLocation W20281350932 @default.
• W2028135093 hasOpenAccess W2028135093 @default.
• W2028135093 hasPrimaryLocation W20281350931 @default.
• W2028135093 hasRelatedWork W1963899904 @default.
• W2028135093 hasRelatedWork W1995277743 @default.

• next