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- W2028136571 abstract "Circulating antibodies were detected by means of a radioimmunological method in thirteen out of nineteen children who had received porcine corticotrophin; no antibodies were detected in a control group. Specific binding of 131I-labelled porcine corticotrophin was distinguished from non-specific, plasma-induced damage by studies based on the reversal after acidification or after the addition of an excess of unlabelled hormone. The antisera were low in titre and avidity, and were directed mainly against the species-specific part of the molecule. The presence of antibodies had no apparent adverse clinical effects, nor was there any demonstrable decrease in the adrenal response to exogenous porcine corticotrophin in therapeutic doses or to endogenous corticotrophin released in response to insulin-induced hypoglycæmia." @default.
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- W2028136571 date "1967-03-01" @default.
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- W2028136571 title "ANTIBODIES TO CORTICOTROPHIN AND THEIR RELATION TO ADRENAL FUNCTION IN CHILDREN RECEIVING CORTICOTROPHIN THERAPY" @default.
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- W2028136571 doi "https://doi.org/10.1016/s0140-6736(67)92544-5" @default.
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