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- W2028137575 endingPage "1163" @default.
- W2028137575 startingPage "1151" @default.
- W2028137575 abstract "Hematopoietic stem cells (HSCs) are functionally defined as cells that upon transplantation into irradiated or otherwise immunocompromised adult organisms provide long-term reconstitution of the entire hematopoietic system. They emerge in the vertebrate conceptus around midgestation. Genetic studies have identified a number of transcription factors and signaling molecules that act at the onset of hematopoiesis, and have begun to delineate the molecular mechanisms underlying the formation of HSCs. One molecule that has been a particularly useful marker of this developmental event in multiple species is Runx1 (also known as AML1, Pebp2a). Runx1 is a sequence-specific DNA-binding protein, that along with its homologues Runx2 and Runx3 and their shared non-DNA binding subunit CBF<B>b</B>, constitute a small family of transcription factors called core-binding factors (CBFs). Runx1 is famous for its role in HSC emergence, and notorious for its involvement in leukemia, as chromosomal rearrangements and inactivating mutations in the human <I>RUNX1</I> gene are some of the most common events in <I>de novo </I>and therapy-related acute myelogenous leukemia, myelodysplastic syndrome and acute lymphocytic leukemia. Here we will review the role of <I>Runx1</I> in HSC emergence in the mouse conceptus and describe some of the genetic pathways that operate upstream and downstream of this gene. Where relevant, we will include data obtained from other species and embryonic stem (ES) cell differentiation cultures." @default.
- W2028137575 created "2016-06-24" @default.
- W2028137575 creator A5009172955 @default.
- W2028137575 creator A5011718225 @default.
- W2028137575 creator A5017920497 @default.
- W2028137575 date "2010-01-01" @default.
- W2028137575 modified "2023-09-26" @default.
- W2028137575 title "Hematopoietic stem cell emergence in the conceptus and the role of Runx1" @default.
- W2028137575 cites W101942087 @default.
- W2028137575 cites W115221593 @default.
- W2028137575 cites W136793466 @default.
- W2028137575 cites W143420532 @default.
- W2028137575 cites W1487837935 @default.
- W2028137575 cites W1503531691 @default.
- W2028137575 cites W1552184745 @default.
- W2028137575 cites W1559931184 @default.
- W2028137575 cites W1603634925 @default.
- W2028137575 cites W1864063551 @default.
- W2028137575 cites W1904595997 @default.
- W2028137575 cites W1937332911 @default.
- W2028137575 cites W1963698034 @default.
- W2028137575 cites W1965060854 @default.
- W2028137575 cites W1966018836 @default.
- W2028137575 cites W1968719918 @default.
- W2028137575 cites W1969631366 @default.
- W2028137575 cites W1970574312 @default.
- W2028137575 cites W1971062749 @default.
- W2028137575 cites W1971069863 @default.
- W2028137575 cites W1971518566 @default.
- W2028137575 cites W1971958267 @default.
- W2028137575 cites W1972942592 @default.
- W2028137575 cites W1973885503 @default.
- W2028137575 cites W1974019849 @default.
- W2028137575 cites W1975607610 @default.
- W2028137575 cites W1975618794 @default.
- W2028137575 cites W1977962361 @default.
- W2028137575 cites W1979211157 @default.
- W2028137575 cites W1980915232 @default.
- W2028137575 cites W1982111644 @default.
- W2028137575 cites W1982721874 @default.
- W2028137575 cites W1985299609 @default.
- W2028137575 cites W1985624978 @default.
- W2028137575 cites W1988697020 @default.
- W2028137575 cites W1989811459 @default.
- W2028137575 cites W1990184382 @default.
- W2028137575 cites W1990565971 @default.
- W2028137575 cites W1990893118 @default.
- W2028137575 cites W1991665242 @default.
- W2028137575 cites W1991766825 @default.
- W2028137575 cites W1991917952 @default.
- W2028137575 cites W1996300461 @default.
- W2028137575 cites W1996351707 @default.
- W2028137575 cites W1998200666 @default.
- W2028137575 cites W1999047431 @default.
- W2028137575 cites W1999401393 @default.
- W2028137575 cites W2000170902 @default.
- W2028137575 cites W2001127255 @default.
- W2028137575 cites W2001242972 @default.
- W2028137575 cites W2001740181 @default.
- W2028137575 cites W2002624276 @default.
- W2028137575 cites W2002921066 @default.
- W2028137575 cites W2007798124 @default.
- W2028137575 cites W2011096612 @default.
- W2028137575 cites W2011239808 @default.
- W2028137575 cites W2011481239 @default.
- W2028137575 cites W2013587414 @default.
- W2028137575 cites W2014375245 @default.
- W2028137575 cites W2015017933 @default.
- W2028137575 cites W2015739079 @default.
- W2028137575 cites W2015932460 @default.
- W2028137575 cites W2019267788 @default.
- W2028137575 cites W2019270922 @default.
- W2028137575 cites W2019586579 @default.
- W2028137575 cites W2019724440 @default.
- W2028137575 cites W2021516648 @default.
- W2028137575 cites W2021582093 @default.
- W2028137575 cites W2022851764 @default.
- W2028137575 cites W2024575580 @default.
- W2028137575 cites W2025545218 @default.
- W2028137575 cites W2028196271 @default.
- W2028137575 cites W2030204567 @default.
- W2028137575 cites W2030608150 @default.
- W2028137575 cites W2030671229 @default.
- W2028137575 cites W2031945557 @default.
- W2028137575 cites W2034663521 @default.
- W2028137575 cites W2034748898 @default.
- W2028137575 cites W2040025747 @default.
- W2028137575 cites W2041514505 @default.
- W2028137575 cites W2042531263 @default.
- W2028137575 cites W2042982622 @default.
- W2028137575 cites W2044354916 @default.
- W2028137575 cites W2044923556 @default.
- W2028137575 cites W2046882508 @default.
- W2028137575 cites W2047582685 @default.
- W2028137575 cites W2047695455 @default.
- W2028137575 cites W2048562617 @default.
- W2028137575 cites W2050376918 @default.
- W2028137575 cites W2050855482 @default.