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• W2028141570 abstract "Comorbidity from tegumentary leishmaniasis and AIDS is poorly characterized.To describe a series of patients coinfected with Leishmania and human immunodeficiency virus (HIV).Clinical records from patients were analysed by demographic data, clinical manifestations, diagnoses, treatments and outcomes.Fifteen cases of AIDS/tegumentary leishmaniasis were found. The diagnosis of leishmaniasis was confirmed by the detection of Leishmania amastigotes or antigens from the cutaneous or mucosal lesions. The mean CD4+ T-cell count was 84 cells mm(-3) (range 8-258) and all patients were classified as having AIDS according to the Centers for Disease Control and Prevention. A wide range of manifestations was found, varying from a single ulcer to multiple and polymorphic lesions. Mucosal lesions were present in 80% and cutaneous lesions in 73% of patients (53% with mucocutaneous form), disseminated lesions in 60% and genital lesions in 27% of patients. All patients received anti-Leishmania therapy and 53% showed relapses. Sixty-seven per cent received highly active antiretroviral therapy but showed no difference in outcomes and relapses compared with those not using medication. Forty per cent died during the study period. In these patients, the anti-Leishmania antibody and Montenegro skin test were useful in the diagnosis of leishmaniasis, probably because leishmaniasis preceded immunosuppression due to HIV infection.Clinical manifestations of tegumentary leishmaniasis in HIV-infected patients are diverse. Our data emphasize possible unusual manifestations of this disease in HIV-infected patients, particularly in severely immunosuppressed cases (< 200 CD4+ cells mm(-3))." @default.
• W2028141570 created "2016-06-24" @default.
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• W2028141570 date "2009-02-01" @default.
• W2028141570 modified "2023-10-02" @default.
• W2028141570 title "Unusual manifestations of tegumentary leishmaniasis in AIDS patients from the New World" @default.
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• W2028141570 doi "https://doi.org/10.1111/j.1365-2133.2008.08908.x" @default.
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