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• W2028142445 abstract "The morphiceptin-derived peptide [Dmt1, d-1-Nal3]morphiceptin, labeled mu-opioid receptor (MOP) with very high affinity and selectivity in the receptor binding assays. In the mouse hot plate test, [Dmt1, d-1-Nal3]morphiceptin given intracerebroventricularly (i.c.v.) produced profound supraspinal analgesia, being approximately 100-fold more potent than the endogenous MOP receptor ligand, endomorphin-2. The antinociceptive effect of this new analog lasted up to 120min. Thus, [Dmt1, d-1-Nal3]morphiceptin is an interesting and extraordinarily potent analgesic, raising the possibility of novel approaches in the design of clinically useful drugs for pain treatment." @default.
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• W2028142445 date "2008-04-01" @default.
• W2028142445 modified "2023-10-18" @default.
• W2028142445 title "[Dmt1, d-1-Nal3]morphiceptin, a novel opioid peptide analog with high analgesic activity" @default.
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• W2028142445 doi "https://doi.org/10.1016/j.peptides.2007.12.005" @default.
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