Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028147914> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2028147914 endingPage "264" @default.
- W2028147914 startingPage "259" @default.
- W2028147914 abstract "We have previously shown that deficiency in the anti-inflammatory cytokine interleukin-10 (IL-10) is responsible for enhanced angiogenesis after hindlimb ischemia. This study examined the putative involvement of matrix metalloproteinase (MMP) activation in this process. Ischemia was produced by artery femoral occlusion in both C57BL6 IL-10(+/+) and IL-10(-/-) mice. Angiographic vessel density and laser Doppler perfusion data at day 28 showed significant improvement in ischemic/nonischemic leg ratio by, respectively, 1.8-fold and 1.4-fold in IL-10(-/-) mice compared with IL-10(+/+) mice. This was associated with an increase in vascular endothelial growth factor (VEGF) protein content in the ischemic hindlimb. Three days after ischemia, gelatin zymography showed a significant increase in both pro- and active forms of MMP-2 and MMP-9 in ischemic hindlimbs of IL-10(-/-) mice compared with IL-10(+/+) mice (P<0.01). This increase in MMP activity in IL-10(-/-) mice was completely inhibited by treatment with BB-94 (5 mg/kg IP), a specific MMP inhibitor. Furthermore, increases in both vessel density and blood perfusion indexes at day 28 in IL-10(-/-) mice were abolished after treatment with BB-94 (0.78+/-0.06 versus 1.17+/-0.09 and 0.62+/-0.02 versus 0.88+/-0.04, for vessel density and blood perfusion ratio, respectively, in IL-10(-/-) mice treated with BB-94 versus untreated IL-10(-/-) mice, P<0.05). In contrast, BB-94 treatment did not affect the rise in VEGF protein content. These findings in IL-10(-/-) mice underscore the critical role of MMP activation, in a context of increased VEGF expression, in promoting ischemia-induced angiogenesis." @default.
- W2028147914 created "2016-06-24" @default.
- W2028147914 creator A5026377797 @default.
- W2028147914 creator A5032199739 @default.
- W2028147914 creator A5036965490 @default.
- W2028147914 creator A5061562246 @default.
- W2028147914 creator A5074641512 @default.
- W2028147914 creator A5090767102 @default.
- W2028147914 date "2001-08-03" @default.
- W2028147914 modified "2023-10-13" @default.
- W2028147914 title "Regulation of Matrix Metalloproteinase Activity in Ischemic Tissue by Interleukin-10" @default.
- W2028147914 cites W1495287184 @default.
- W2028147914 cites W1649452503 @default.
- W2028147914 cites W1673084462 @default.
- W2028147914 cites W1984584032 @default.
- W2028147914 cites W1994183472 @default.
- W2028147914 cites W2005961677 @default.
- W2028147914 cites W2016411107 @default.
- W2028147914 cites W2032945902 @default.
- W2028147914 cites W2038613403 @default.
- W2028147914 cites W2042231871 @default.
- W2028147914 cites W2063259891 @default.
- W2028147914 cites W2108110626 @default.
- W2028147914 cites W2124462138 @default.
- W2028147914 cites W4293247451 @default.
- W2028147914 doi "https://doi.org/10.1161/hh1501.094269" @default.
- W2028147914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11485976" @default.
- W2028147914 hasPublicationYear "2001" @default.
- W2028147914 type Work @default.
- W2028147914 sameAs 2028147914 @default.
- W2028147914 citedByCount "79" @default.
- W2028147914 countsByYear W20281479142013 @default.
- W2028147914 countsByYear W20281479142014 @default.
- W2028147914 countsByYear W20281479142015 @default.
- W2028147914 countsByYear W20281479142016 @default.
- W2028147914 countsByYear W20281479142017 @default.
- W2028147914 countsByYear W20281479142018 @default.
- W2028147914 countsByYear W20281479142019 @default.
- W2028147914 countsByYear W20281479142020 @default.
- W2028147914 countsByYear W20281479142021 @default.
- W2028147914 countsByYear W20281479142022 @default.
- W2028147914 countsByYear W20281479142023 @default.
- W2028147914 crossrefType "journal-article" @default.
- W2028147914 hasAuthorship W2028147914A5026377797 @default.
- W2028147914 hasAuthorship W2028147914A5032199739 @default.
- W2028147914 hasAuthorship W2028147914A5036965490 @default.
- W2028147914 hasAuthorship W2028147914A5061562246 @default.
- W2028147914 hasAuthorship W2028147914A5074641512 @default.
- W2028147914 hasAuthorship W2028147914A5090767102 @default.
- W2028147914 hasBestOaLocation W20281479141 @default.
- W2028147914 hasConcept C109523444 @default.
- W2028147914 hasConcept C126322002 @default.
- W2028147914 hasConcept C134018914 @default.
- W2028147914 hasConcept C146957229 @default.
- W2028147914 hasConcept C167734588 @default.
- W2028147914 hasConcept C177430391 @default.
- W2028147914 hasConcept C185592680 @default.
- W2028147914 hasConcept C2777025900 @default.
- W2028147914 hasConcept C2777663904 @default.
- W2028147914 hasConcept C2778690821 @default.
- W2028147914 hasConcept C2780394083 @default.
- W2028147914 hasConcept C541997718 @default.
- W2028147914 hasConcept C71924100 @default.
- W2028147914 hasConcept C74172505 @default.
- W2028147914 hasConceptScore W2028147914C109523444 @default.
- W2028147914 hasConceptScore W2028147914C126322002 @default.
- W2028147914 hasConceptScore W2028147914C134018914 @default.
- W2028147914 hasConceptScore W2028147914C146957229 @default.
- W2028147914 hasConceptScore W2028147914C167734588 @default.
- W2028147914 hasConceptScore W2028147914C177430391 @default.
- W2028147914 hasConceptScore W2028147914C185592680 @default.
- W2028147914 hasConceptScore W2028147914C2777025900 @default.
- W2028147914 hasConceptScore W2028147914C2777663904 @default.
- W2028147914 hasConceptScore W2028147914C2778690821 @default.
- W2028147914 hasConceptScore W2028147914C2780394083 @default.
- W2028147914 hasConceptScore W2028147914C541997718 @default.
- W2028147914 hasConceptScore W2028147914C71924100 @default.
- W2028147914 hasConceptScore W2028147914C74172505 @default.
- W2028147914 hasIssue "3" @default.
- W2028147914 hasLocation W20281479141 @default.
- W2028147914 hasLocation W20281479142 @default.
- W2028147914 hasOpenAccess W2028147914 @default.
- W2028147914 hasPrimaryLocation W20281479141 @default.
- W2028147914 hasRelatedWork W1972933415 @default.
- W2028147914 hasRelatedWork W1975936928 @default.
- W2028147914 hasRelatedWork W1980902990 @default.
- W2028147914 hasRelatedWork W2028067028 @default.
- W2028147914 hasRelatedWork W2042303973 @default.
- W2028147914 hasRelatedWork W2087087143 @default.
- W2028147914 hasRelatedWork W2383320628 @default.
- W2028147914 hasRelatedWork W2421372801 @default.
- W2028147914 hasRelatedWork W2680992019 @default.
- W2028147914 hasRelatedWork W2782857268 @default.
- W2028147914 hasVolume "89" @default.
- W2028147914 isParatext "false" @default.
- W2028147914 isRetracted "false" @default.
- W2028147914 magId "2028147914" @default.
- W2028147914 workType "article" @default.