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- W2028156729 abstract "Integrins link the inside of a cell with its outside environment and in doing so regulate a wide variety of cell behaviors. Integrins are well known for their roles in angiogenesis and cell migration but their functions in bone formation are less clear. The majority of integrin signaling proceeds through focal adhesion kinase (FAK), an essential component of the focal adhesion complex. We generated transgenic mice in which FAK was deleted in osteoblasts and uncovered a previously unknown role in osteoblast differentiation associated with bone healing. FAK mutant cells migrated to the site of skeletal injury and angiogenesis was unaffected yet the transgenic mice still exhibited numerous defects in reparative bone formation. Osteoblast differentiation itself was unperturbed by the loss of FAK, whereas the attachment of osteoclasts to the bone matrix was disrupted in vivo. We postulate that defective bi-directional integrin signaling affects the organization of the collagen matrix. Finally, we present a compensatory candidate molecule, Pyk2, which localized to the focal adhesions in osteoblasts that were lacking FAK." @default.
- W2028156729 created "2016-06-24" @default.
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- W2028156729 creator A5086650077 @default.
- W2028156729 date "2007-07-01" @default.
- W2028156729 modified "2023-09-26" @default.
- W2028156729 title "Reconciling the roles of FAK in osteoblast differentiation, osteoclast remodeling, and bone regeneration" @default.
- W2028156729 cites W1549544590 @default.
- W2028156729 cites W1565536510 @default.
- W2028156729 cites W1574213882 @default.
- W2028156729 cites W1608914198 @default.
- W2028156729 cites W1785533687 @default.
- W2028156729 cites W1845277443 @default.
- W2028156729 cites W1865638244 @default.
- W2028156729 cites W1905978178 @default.
- W2028156729 cites W1926397135 @default.
- W2028156729 cites W1929023701 @default.
- W2028156729 cites W1964264991 @default.
- W2028156729 cites W1975621622 @default.
- W2028156729 cites W1983228354 @default.
- W2028156729 cites W1984872320 @default.
- W2028156729 cites W1992613549 @default.
- W2028156729 cites W1996013872 @default.
- W2028156729 cites W1997121235 @default.
- W2028156729 cites W1997812904 @default.
- W2028156729 cites W2001431467 @default.
- W2028156729 cites W2001675896 @default.
- W2028156729 cites W2006090280 @default.
- W2028156729 cites W2009024878 @default.
- W2028156729 cites W2013650960 @default.
- W2028156729 cites W2014280822 @default.
- W2028156729 cites W2015050458 @default.
- W2028156729 cites W2021053451 @default.
- W2028156729 cites W2022049814 @default.
- W2028156729 cites W2022982831 @default.
- W2028156729 cites W2023680421 @default.
- W2028156729 cites W2025018535 @default.
- W2028156729 cites W2028691987 @default.
- W2028156729 cites W2029287842 @default.
- W2028156729 cites W2035660111 @default.
- W2028156729 cites W2036908471 @default.
- W2028156729 cites W2038051362 @default.
- W2028156729 cites W2046155579 @default.
- W2028156729 cites W2046409934 @default.
- W2028156729 cites W2050014442 @default.
- W2028156729 cites W2050093300 @default.
- W2028156729 cites W2056104802 @default.
- W2028156729 cites W2060057909 @default.
- W2028156729 cites W2061608358 @default.
- W2028156729 cites W2063277829 @default.
- W2028156729 cites W2064896821 @default.
- W2028156729 cites W2071852938 @default.
- W2028156729 cites W2073002574 @default.
- W2028156729 cites W2074061232 @default.
- W2028156729 cites W2078766771 @default.
- W2028156729 cites W2086992732 @default.
- W2028156729 cites W2087122586 @default.
- W2028156729 cites W2091823133 @default.
- W2028156729 cites W2100039503 @default.
- W2028156729 cites W2103363752 @default.
- W2028156729 cites W2105356859 @default.
- W2028156729 cites W2108105475 @default.
- W2028156729 cites W2116045343 @default.
- W2028156729 cites W2116312858 @default.
- W2028156729 cites W2121645463 @default.
- W2028156729 cites W2125272276 @default.
- W2028156729 cites W2127286098 @default.
- W2028156729 cites W2129611079 @default.
- W2028156729 cites W2131734392 @default.
- W2028156729 cites W2138231208 @default.
- W2028156729 cites W2139471842 @default.
- W2028156729 cites W2145655068 @default.
- W2028156729 cites W2149697928 @default.
- W2028156729 cites W2152077161 @default.
- W2028156729 cites W2161873278 @default.
- W2028156729 cites W2162467077 @default.
- W2028156729 cites W2164330595 @default.
- W2028156729 cites W2166113302 @default.
- W2028156729 cites W2168197406 @default.
- W2028156729 cites W2169563230 @default.
- W2028156729 cites W2398338990 @default.
- W2028156729 cites W2400570794 @default.
- W2028156729 cites W2465984650 @default.
- W2028156729 cites W4232534952 @default.
- W2028156729 cites W4234113840 @default.
- W2028156729 cites W4235374179 @default.
- W2028156729 cites W4249092084 @default.
- W2028156729 cites W4289961145 @default.
- W2028156729 cites W2396827028 @default.
- W2028156729 doi "https://doi.org/10.1016/j.bone.2007.01.024" @default.
- W2028156729 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2699353" @default.
- W2028156729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17459803" @default.
- W2028156729 hasPublicationYear "2007" @default.