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- W2028158229 abstract "Abstract Chickens bursectomized (tailectomized) at 60 hr of incubation were tested for antibody and immunoglobulin production at the age of 1–6 months. They were immunized at the age of 5 weeks with HGG, Brucella, and SRBC, at the age of 10 weeks with diphtheriatetanus-pertussis vaccine and levan, and at the age of 16 weeks with Escherichia coli LPS and Salmonella. Each antigen was administered intraperitoneally three times, with one-week intervals. Four of the eight animals studied showed virtually no antibody response of IgM, IgG, or IgA class against any of the antigens studied. Four chickens showed a normal or intermediate response indicating an incomplete bursectomy. The bursectomized birds, including those without any specific antibody response had good amounts of IgM, IgG, and IgA in the serum. Our findings indicate that the bursa of Fabricius is essential for activation of the V gene repertoire. Some specificities, the nature of which still remain undetermined, may develop extrabursally, and the same applies for the switch from IgM to IgG and IgA production." @default.
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- W2028158229 date "1982-05-01" @default.
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- W2028158229 title "Immune capacity of the chicken bursectomized at 60 hr of incubation: Production of the immunoglobulins and specific antibodies" @default.
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- W2028158229 doi "https://doi.org/10.1016/0090-1229(82)90130-1" @default.
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