Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028160966> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2028160966 endingPage "963" @default.
- W2028160966 startingPage "959" @default.
- W2028160966 abstract "RK-28 is one of the new hypoxic cell radiosensitizers being developed in Japan and has been tested clinically. To reduce its toxicity and increase its sensitizing activity, intratumoral injection of RK-28 was performed during intraoperative radiation therapy for pancreatic cancer. This report presents the results of pharmacokinetic studies performed in 10 of the 17 patients who were administrated intravenous or intratumoral RK-28 during intraoperative radiation therapy. No adverse effects were noted following intravenous or intratumoral injection of the drug. Pharmacokinetic studies demonstrated several metabolites of RK-28 in both serum and tumor tissues. After intratumoral injection, the tumor drug concentration ranged from 123 micrograms/g to 9,292 micrograms/g just after intraoperative radiation therapy (30-50 min after injection of the compound), while the serum concentration ranged from 4.1 to 9.8 micrograms/ml. The tumor drug concentration was 23.3 micrograms/g at 45 min after intravenous injection of RK-28. Thus, intratumoral injection of RK-28 was superior to intravenous administration in this pharmacokinetic study. The combination of intraoperative radiation therapy and intratumoral injection of RK-28 appears to be a feasible treatment method." @default.
- W2028160966 created "2016-06-24" @default.
- W2028160966 creator A5016913797 @default.
- W2028160966 creator A5036554469 @default.
- W2028160966 creator A5040691530 @default.
- W2028160966 creator A5054458732 @default.
- W2028160966 creator A5055693886 @default.
- W2028160966 creator A5066274607 @default.
- W2028160966 creator A5071240286 @default.
- W2028160966 date "1992-01-01" @default.
- W2028160966 modified "2023-10-18" @default.
- W2028160966 title "Pharmacokinetics of intratumoral RK-28, a new hypoxic radiosensitizer" @default.
- W2028160966 cites W1965636506 @default.
- W2028160966 cites W1967062148 @default.
- W2028160966 cites W1969082094 @default.
- W2028160966 cites W1977196597 @default.
- W2028160966 cites W1994555849 @default.
- W2028160966 cites W1996519451 @default.
- W2028160966 cites W2003290570 @default.
- W2028160966 cites W2012008726 @default.
- W2028160966 cites W2041276622 @default.
- W2028160966 cites W2045658902 @default.
- W2028160966 cites W2055522497 @default.
- W2028160966 cites W2058180816 @default.
- W2028160966 cites W2064168107 @default.
- W2028160966 cites W2066082960 @default.
- W2028160966 cites W2071158076 @default.
- W2028160966 cites W2072583427 @default.
- W2028160966 cites W2075215324 @default.
- W2028160966 cites W2076662567 @default.
- W2028160966 cites W2079854430 @default.
- W2028160966 cites W2097813123 @default.
- W2028160966 cites W2140585471 @default.
- W2028160966 cites W2141575226 @default.
- W2028160966 cites W2150293333 @default.
- W2028160966 cites W2150801415 @default.
- W2028160966 cites W2330475465 @default.
- W2028160966 doi "https://doi.org/10.1016/0360-3016(92)90480-6" @default.
- W2028160966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1447037" @default.
- W2028160966 hasPublicationYear "1992" @default.
- W2028160966 type Work @default.
- W2028160966 sameAs 2028160966 @default.
- W2028160966 citedByCount "3" @default.
- W2028160966 crossrefType "journal-article" @default.
- W2028160966 hasAuthorship W2028160966A5016913797 @default.
- W2028160966 hasAuthorship W2028160966A5036554469 @default.
- W2028160966 hasAuthorship W2028160966A5040691530 @default.
- W2028160966 hasAuthorship W2028160966A5054458732 @default.
- W2028160966 hasAuthorship W2028160966A5055693886 @default.
- W2028160966 hasAuthorship W2028160966A5066274607 @default.
- W2028160966 hasAuthorship W2028160966A5071240286 @default.
- W2028160966 hasConcept C112705442 @default.
- W2028160966 hasConcept C126322002 @default.
- W2028160966 hasConcept C197934379 @default.
- W2028160966 hasConcept C2776428644 @default.
- W2028160966 hasConcept C2780035454 @default.
- W2028160966 hasConcept C29730261 @default.
- W2028160966 hasConcept C509974204 @default.
- W2028160966 hasConcept C71924100 @default.
- W2028160966 hasConcept C98274493 @default.
- W2028160966 hasConceptScore W2028160966C112705442 @default.
- W2028160966 hasConceptScore W2028160966C126322002 @default.
- W2028160966 hasConceptScore W2028160966C197934379 @default.
- W2028160966 hasConceptScore W2028160966C2776428644 @default.
- W2028160966 hasConceptScore W2028160966C2780035454 @default.
- W2028160966 hasConceptScore W2028160966C29730261 @default.
- W2028160966 hasConceptScore W2028160966C509974204 @default.
- W2028160966 hasConceptScore W2028160966C71924100 @default.
- W2028160966 hasConceptScore W2028160966C98274493 @default.
- W2028160966 hasIssue "5" @default.
- W2028160966 hasLocation W20281609661 @default.
- W2028160966 hasLocation W20281609662 @default.
- W2028160966 hasOpenAccess W2028160966 @default.
- W2028160966 hasPrimaryLocation W20281609661 @default.
- W2028160966 hasRelatedWork W1969876219 @default.
- W2028160966 hasRelatedWork W1978032370 @default.
- W2028160966 hasRelatedWork W1979757582 @default.
- W2028160966 hasRelatedWork W1990964652 @default.
- W2028160966 hasRelatedWork W2049819497 @default.
- W2028160966 hasRelatedWork W2076844872 @default.
- W2028160966 hasRelatedWork W2332367370 @default.
- W2028160966 hasRelatedWork W2400461952 @default.
- W2028160966 hasRelatedWork W4205993769 @default.
- W2028160966 hasRelatedWork W79555446 @default.
- W2028160966 hasVolume "24" @default.
- W2028160966 isParatext "false" @default.
- W2028160966 isRetracted "false" @default.
- W2028160966 magId "2028160966" @default.
- W2028160966 workType "article" @default.