Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028170369> ?p ?o ?g. }
- W2028170369 endingPage "13707" @default.
- W2028170369 startingPage "13697" @default.
- W2028170369 abstract "ABSTRACT Interferon-inducible transmembrane (IFITM) protein family members IFITM1, -2, and -3 restrict the infection of multiple enveloped viruses. Significant enrichment of a minor IFITM3 allele was recently reported for patients who were hospitalized for seasonal and 2009 H1N1 pandemic flu. This IFITM3 allele lacks the region corresponding to the first amino-terminal 21 amino acids and is unable to inhibit influenza A virus. In this study, we found that deleting this 21-amino-acid region relocates IFITM3 from the endosomal compartments to the cell periphery. This finding likely underlies the lost inhibition of influenza A virus that completes its entry exclusively within endosomes at low pH. Yet, wild-type IFITM3 and the mutant with the 21-amino-acid deletion inhibit HIV-1 replication equally well. Given the pH-independent nature of HIV-1 entry, our results suggest that IFITM3 can inhibit viruses that enter cells via different routes and that its N-terminal region is specifically required for controlling pH-dependent viruses." @default.
- W2028170369 created "2016-06-24" @default.
- W2028170369 creator A5023867715 @default.
- W2028170369 creator A5034031384 @default.
- W2028170369 creator A5044530218 @default.
- W2028170369 creator A5062868933 @default.
- W2028170369 creator A5064658611 @default.
- W2028170369 creator A5068178447 @default.
- W2028170369 creator A5070237210 @default.
- W2028170369 creator A5075418063 @default.
- W2028170369 date "2012-12-15" @default.
- W2028170369 modified "2023-10-12" @default.
- W2028170369 title "The N-Terminal Region of IFITM3 Modulates Its Antiviral Activity by Regulating IFITM3 Cellular Localization" @default.
- W2028170369 cites W1494227533 @default.
- W2028170369 cites W1607207125 @default.
- W2028170369 cites W1656644300 @default.
- W2028170369 cites W1979358876 @default.
- W2028170369 cites W1982606786 @default.
- W2028170369 cites W1991683855 @default.
- W2028170369 cites W1995684348 @default.
- W2028170369 cites W2003988251 @default.
- W2028170369 cites W2009465113 @default.
- W2028170369 cites W2016967864 @default.
- W2028170369 cites W2021349374 @default.
- W2028170369 cites W2029379203 @default.
- W2028170369 cites W2031549005 @default.
- W2028170369 cites W2034175657 @default.
- W2028170369 cites W2034324831 @default.
- W2028170369 cites W2039028257 @default.
- W2028170369 cites W2041524641 @default.
- W2028170369 cites W2048648611 @default.
- W2028170369 cites W2055677723 @default.
- W2028170369 cites W2060343311 @default.
- W2028170369 cites W2060534902 @default.
- W2028170369 cites W2071559289 @default.
- W2028170369 cites W2076134341 @default.
- W2028170369 cites W2077620427 @default.
- W2028170369 cites W2078646756 @default.
- W2028170369 cites W2086262311 @default.
- W2028170369 cites W2090306908 @default.
- W2028170369 cites W2090895449 @default.
- W2028170369 cites W2097928174 @default.
- W2028170369 cites W2106230884 @default.
- W2028170369 cites W2107380548 @default.
- W2028170369 cites W2114421191 @default.
- W2028170369 cites W2119651818 @default.
- W2028170369 cites W2129159114 @default.
- W2028170369 cites W2135264287 @default.
- W2028170369 cites W2148351021 @default.
- W2028170369 cites W2156480395 @default.
- W2028170369 cites W2163391867 @default.
- W2028170369 cites W2164084422 @default.
- W2028170369 cites W2167331562 @default.
- W2028170369 cites W2614446987 @default.
- W2028170369 doi "https://doi.org/10.1128/jvi.01828-12" @default.
- W2028170369 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3503121" @default.
- W2028170369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23055554" @default.
- W2028170369 hasPublicationYear "2012" @default.
- W2028170369 type Work @default.
- W2028170369 sameAs 2028170369 @default.
- W2028170369 citedByCount "153" @default.
- W2028170369 countsByYear W20281703692013 @default.
- W2028170369 countsByYear W20281703692014 @default.
- W2028170369 countsByYear W20281703692015 @default.
- W2028170369 countsByYear W20281703692016 @default.
- W2028170369 countsByYear W20281703692017 @default.
- W2028170369 countsByYear W20281703692018 @default.
- W2028170369 countsByYear W20281703692019 @default.
- W2028170369 countsByYear W20281703692020 @default.
- W2028170369 countsByYear W20281703692021 @default.
- W2028170369 countsByYear W20281703692022 @default.
- W2028170369 countsByYear W20281703692023 @default.
- W2028170369 crossrefType "journal-article" @default.
- W2028170369 hasAuthorship W2028170369A5023867715 @default.
- W2028170369 hasAuthorship W2028170369A5034031384 @default.
- W2028170369 hasAuthorship W2028170369A5044530218 @default.
- W2028170369 hasAuthorship W2028170369A5062868933 @default.
- W2028170369 hasAuthorship W2028170369A5064658611 @default.
- W2028170369 hasAuthorship W2028170369A5068178447 @default.
- W2028170369 hasAuthorship W2028170369A5070237210 @default.
- W2028170369 hasAuthorship W2028170369A5075418063 @default.
- W2028170369 hasBestOaLocation W20281703691 @default.
- W2028170369 hasConcept C102747710 @default.
- W2028170369 hasConcept C104317684 @default.
- W2028170369 hasConcept C140704245 @default.
- W2028170369 hasConcept C143065580 @default.
- W2028170369 hasConcept C1491633281 @default.
- W2028170369 hasConcept C159047783 @default.
- W2028170369 hasConcept C170493617 @default.
- W2028170369 hasConcept C24530287 @default.
- W2028170369 hasConcept C2522874641 @default.
- W2028170369 hasConcept C2776178377 @default.
- W2028170369 hasConcept C2777546802 @default.
- W2028170369 hasConcept C515207424 @default.
- W2028170369 hasConcept C54355233 @default.
- W2028170369 hasConcept C86803240 @default.
- W2028170369 hasConcept C95444343 @default.
- W2028170369 hasConceptScore W2028170369C102747710 @default.