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- W2028179929 abstract "Cardiac assist devices unload ventricular volume and restore the circulation as a bridge to transplant in heart failure patients. In some cases, patients have been successfully weaned from the device following myocardial recovery. Assuming optimal coupling of the left ventricle to the vasculature promotes myocardial recovery, a novel control strategy for an artificial vasculature device (AVD) was developed using a dynamic system simulator (Simulink, MathWorks). The theory is to allow the heart to fill to its normal volume, increase coronary perfusion, and eject against a lower afterload, facilitating myocardial recovery. In practice, the heart ejects its stroke volume (SV) into an AVD anastamosed to the aortic arch that can produce any desired afterload including no load condition. During diastole, the AVD returns SV providing counter pulsation. The AVD can be programmed to mimic user-defined systemic input impedance that includes resistance, elastance, and inertial components. In the simulation, an aortic flow waveform was injected into a 2-element Windkessel arterial model and the resulting target arterial pressure was calculated. The control system is programmed to minimize the error between the target and AVD pressures during ejection. A dynamic system simulation was conducted to predict pressure, volume, actuator displacement, and force feedback of the AVD demonstrating feasibility of this approach. Currently, a prototype AVD and control strategy are being tested using a mock circulation system under normal and failing heart conditions." @default.
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- W2028179929 date "2003-03-01" @default.
- W2028179929 modified "2023-09-26" @default.
- W2028179929 title "CONTROL STRATEGY FOR AN ARTIFICIAL VASCULAR UNLOADING DEVICE" @default.
- W2028179929 doi "https://doi.org/10.1097/00002480-200303000-00052" @default.
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