Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028193992> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2028193992 endingPage "444" @default.
- W2028193992 startingPage "439" @default.
- W2028193992 abstract "Phenazopyridine hydrochloride is a strong analgesic used in the treatment of urinary tract infections. The aim of the present study was to develop a procedure based on gas chromatography-mass spectrometry (GC-MS) for the analysis of phenazopyridine in rat plasma. The method was set up and adapted for the analysis of small biological samples taken from rats. Biological samples were extracted by liquid-liquid extraction. The extraction agent was ethyl acetate. The samples were separated by GC on a DB-5MS analytical column and determined by a quadrupole mass spectrometer detector operated under selected ion monitoring mode. Excellent linearity was found between 0.01 and 1.00 microg/ml (r = 0.9991, n = 9) for plasma samples. The limit of detection (LOD) was 0.3 ng/ml. Within-day and between-day precisions expressed as the relative standard deviation (RSD) for the method were 1.83-4.91% and 2.12-4.76%, respectively. The recoveries for all samples were >90%. The main pharmacokinetic parameters obtained were T(max) = (0.35+/-0.01) h, C(max) = (0.396+/-0.079) microg/ml, AUC = (0.373+/-0.065) h microg/ml and CL = (94.2+/-5.9) ml/g/h. The results presented here clearly indicate that this proposed method could be applicable to investigate the pharmacokinetic of phenazopyridine in rats after administration. (c)" @default.
- W2028193992 created "2016-06-24" @default.
- W2028193992 creator A5005829172 @default.
- W2028193992 creator A5013340880 @default.
- W2028193992 creator A5013661103 @default.
- W2028193992 creator A5052071826 @default.
- W2028193992 creator A5063780030 @default.
- W2028193992 creator A5069596466 @default.
- W2028193992 date "2007-01-01" @default.
- W2028193992 modified "2023-09-28" @default.
- W2028193992 title "Development and validation of a gas chromatography-mass spectrometry method for the determination of phenazopyridine in rat plasma: application to the pharmacokinetic study" @default.
- W2028193992 cites W1974948197 @default.
- W2028193992 cites W1977528487 @default.
- W2028193992 cites W1997691563 @default.
- W2028193992 cites W2001187937 @default.
- W2028193992 cites W2022649089 @default.
- W2028193992 cites W2038205257 @default.
- W2028193992 cites W2040906288 @default.
- W2028193992 cites W2044233356 @default.
- W2028193992 cites W2045784106 @default.
- W2028193992 cites W2058123350 @default.
- W2028193992 cites W2066983297 @default.
- W2028193992 cites W2067345835 @default.
- W2028193992 cites W2090726987 @default.
- W2028193992 cites W2127383228 @default.
- W2028193992 cites W2141841750 @default.
- W2028193992 cites W2151520572 @default.
- W2028193992 cites W2154154881 @default.
- W2028193992 cites W4301043212 @default.
- W2028193992 doi "https://doi.org/10.1002/bdd.567" @default.
- W2028193992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17847064" @default.
- W2028193992 hasPublicationYear "2007" @default.
- W2028193992 type Work @default.
- W2028193992 sameAs 2028193992 @default.
- W2028193992 citedByCount "18" @default.
- W2028193992 countsByYear W20281939922012 @default.
- W2028193992 countsByYear W20281939922013 @default.
- W2028193992 countsByYear W20281939922014 @default.
- W2028193992 countsByYear W20281939922015 @default.
- W2028193992 countsByYear W20281939922016 @default.
- W2028193992 countsByYear W20281939922017 @default.
- W2028193992 countsByYear W20281939922018 @default.
- W2028193992 countsByYear W20281939922019 @default.
- W2028193992 countsByYear W20281939922020 @default.
- W2028193992 crossrefType "journal-article" @default.
- W2028193992 hasAuthorship W2028193992A5005829172 @default.
- W2028193992 hasAuthorship W2028193992A5013340880 @default.
- W2028193992 hasAuthorship W2028193992A5013661103 @default.
- W2028193992 hasAuthorship W2028193992A5052071826 @default.
- W2028193992 hasAuthorship W2028193992A5063780030 @default.
- W2028193992 hasAuthorship W2028193992A5069596466 @default.
- W2028193992 hasConcept C112705442 @default.
- W2028193992 hasConcept C119128265 @default.
- W2028193992 hasConcept C123460561 @default.
- W2028193992 hasConcept C162356407 @default.
- W2028193992 hasConcept C179302884 @default.
- W2028193992 hasConcept C185592680 @default.
- W2028193992 hasConcept C205345274 @default.
- W2028193992 hasConcept C2779858419 @default.
- W2028193992 hasConcept C43617362 @default.
- W2028193992 hasConcept C4725764 @default.
- W2028193992 hasConcept C71924100 @default.
- W2028193992 hasConcept C98274493 @default.
- W2028193992 hasConceptScore W2028193992C112705442 @default.
- W2028193992 hasConceptScore W2028193992C119128265 @default.
- W2028193992 hasConceptScore W2028193992C123460561 @default.
- W2028193992 hasConceptScore W2028193992C162356407 @default.
- W2028193992 hasConceptScore W2028193992C179302884 @default.
- W2028193992 hasConceptScore W2028193992C185592680 @default.
- W2028193992 hasConceptScore W2028193992C205345274 @default.
- W2028193992 hasConceptScore W2028193992C2779858419 @default.
- W2028193992 hasConceptScore W2028193992C43617362 @default.
- W2028193992 hasConceptScore W2028193992C4725764 @default.
- W2028193992 hasConceptScore W2028193992C71924100 @default.
- W2028193992 hasConceptScore W2028193992C98274493 @default.
- W2028193992 hasIssue "8" @default.
- W2028193992 hasLocation W20281939921 @default.
- W2028193992 hasLocation W20281939922 @default.
- W2028193992 hasOpenAccess W2028193992 @default.
- W2028193992 hasPrimaryLocation W20281939921 @default.
- W2028193992 hasRelatedWork W1975251544 @default.
- W2028193992 hasRelatedWork W1989479194 @default.
- W2028193992 hasRelatedWork W2009778826 @default.
- W2028193992 hasRelatedWork W2021585491 @default.
- W2028193992 hasRelatedWork W2153676202 @default.
- W2028193992 hasRelatedWork W2369299066 @default.
- W2028193992 hasRelatedWork W287047683 @default.
- W2028193992 hasRelatedWork W3043476608 @default.
- W2028193992 hasRelatedWork W3161614177 @default.
- W2028193992 hasRelatedWork W4231922850 @default.
- W2028193992 hasVolume "28" @default.
- W2028193992 isParatext "false" @default.
- W2028193992 isRetracted "false" @default.
- W2028193992 magId "2028193992" @default.
- W2028193992 workType "article" @default.