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• W2028201159 abstract "After tetracycline hydrochloride (TC) treatment for 48 h, we obtained 8-azaguanine-resistant mutants in a population of cultured Chinese hamster cells. Optimal expression of mutation was reached after about 5 days, and mutation frequency remained constant thereafter. There was a gradual increase in the yield of mutants with increasing doses of TC, and measurable yield was observed at a dose as low as 10 μ g of TC per ml. When the cells, before or after the TC treatment, were grown in presence of l -ascorbic acid (10 or 20 μg/ml) for 48 h, there was significant decrease in the frequency of mutation induced by TC. If lk -ascorbic acid were present at the same concentration during the treatment with TC, no significant influence on the induction of mutants by TC was detected." @default.
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• W2028201159 date "1982-06-01" @default.
• W2028201159 modified "2023-09-26" @default.
• W2028201159 title "Tetracycline-induced mutation in cultured Chinese hamster cells" @default.
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• W2028201159 doi "https://doi.org/10.1016/0165-1218(82)90126-4" @default.
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