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• W2028202456 abstract "Background and Aim: Cardiac dysfunction in cirrhosis is a problem of the ‘blind side of the heart’. Without firm diagnostic criteria, the exact prevalence of cirrhotic cardiomyopathy remains unknown. We evaluate left ventricle (LV) standard echocardiographic (Echokg) and colour Doppler myocardial imaging (DMI) pattern of cirrhotic patients (pts) with the aim to assess correlation with Child–Pugh score. Patients and Methods: 58 of pts (27 males, 31 females, age 53.6±11.6 years) with liver cirrhosis of various etiology and 21 healthy controls (14 males, 7 females, age 49.0±12.0 years) were studied. Cirrhosis stage was evaluated by Child–Pugh scoring. All subjects had undergone 2D and colour DMI. Results: No clear differences between standard Echokg parameters depicting LV systole and diastole were noticed. Slight increase of LV and left atrium size was observed in the cirrhotic pts as compared with controls (Fisher exact test: p = 0.0489 and p = 0.0015, respectively). Also weak correlation of EF and E, A waves with cirrhosis score was found (Spearman correlation: CEF = 0.32109, p = 0.0039; CE = 0.22771, p = 0.0436; CA = 0.41774, p = 0.0001). Meanwhile cirrhotic pts had markedly decreased septal and mean Ea which further deteriorated depending on cirrhosis score (Spearman correlation: CEa mean= −0.78686, p< 0.0001; CEa septal= −0.78176, p< 0.0001). Filling pressure (E/Ea) was upgraded in the cirrhotic pts (Spearman correlation: CE/Ea= 0.65457, p< 0.0001), that was more pronounced in the Child– Pugh C group (controls vs C: 0.084 vs 0.17). Longitudinal systolic function estimated by mean strain (S) and strain rate (SR) was decreased in the cirrhotic pts compared with controls (Spearman correlation: CS = −0.54209, p< 0.0001; CSRS = −0.46828, p< 0.0001). S and SR were positively correlated with diastolic septal and mean mitral anular Ea (Pearson correlation: CS and Ea septal = 0.493, p< 0.0001; CS and Ea mean = 0.451, p< 0.0001; CSR and Ea septal = 0.540, p< 0.0001; CSR and Ea mean = 0.508, p< 0.0001). Conclusions: DMI indices might be a useful tool in predicting cardiac dysfunction in cirrhotic patients. Following parameters mean and septal annulus Ea, filling pressure E/Ea and mean longitudinal strain and strain rate may therefore represent the best available screening test to diagnose the cirrhotic cardiomyopathy syndrome." @default.
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• W2028202456 date "2009-04-01" @default.
• W2028202456 modified "2023-09-26" @default.
• W2028202456 title "197 REFRACOTRY SPONTANEOUS BACTERIAL PERITONITIS: A RETROSPECTIVE STUDY OF THE UNIVERSITY OF CHICAGO EXPERIENCE" @default.
• W2028202456 doi "https://doi.org/10.1016/s0168-8278(09)60199-9" @default.
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