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- W2028205689 abstract "The physiological status of presynaptic receptors, regulating sympathetic neurotransmitter release, remains subject to debate. Nevertheless, pharmacological techniques have shown presynaptic alpha-adrenoceptors, mediating a negative feedback inhibition of neuronal noradrenaline (NA) release, and presynaptic beta-adrenoceptors mediating a positive feedback facilitation. Decreased presynaptic alpha- or increased beta-adrenoceptor responsiveness might be expected to result in enhanced per-pulse release of NA and may contribute to hypertension development and maintenance. A potential role in hypertension development, but not its maintenance, has been established for presynaptic beta-adrenoceptors. Attempts to identify altered presynaptic adrenoceptor responsiveness in hypertension have, however, been inconclusive." @default.
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- W2028205689 date "1990-08-01" @default.
- W2028205689 modified "2023-09-27" @default.
- W2028205689 title "Presynaptic Receptors in Hypertension" @default.
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- W2028205689 doi "https://doi.org/10.1111/j.1749-6632.1990.tb32007.x" @default.
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